CAS: 645-56-7; 4-Propylphenol

该化合物是一种有机化合物,属于烷酚类,其特点是附于苯球环的丙基类,该化合物通常用作合成特殊化学品的中间体,包括香气,药品和农用化学品,其苯酚结构使得在电益酚替代和凝聚反应中具有回活动性,使其对衍生值值. 4-popylphenol表现出有机溶剂的中等溶性,水溶性有限,便于其在有机合成中使用. 丙基亚基基可增强脂性,这在需要水分辨相互作用的应用中可能具有优势. 建议妥善处理,因为其潜在的刺激性.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

  • 9005-53-2 = 645-56-7 + 89-72-5 + 2944-49-2 + 2082-61-3 + 1123-94-0 + 1197-34-8 + 2049-95-8 + 3637-01-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium; 1 H,350 °C; 4 H,350 °C
    标题:Catalytic Hydrotreatment Of Pyrolytic Lignins From Different Sources To Biobased Chemicals: Identification Of Feed-Product Relations
    作者:Figueiredo,M. B.; Deuss,P. J.; Venderbosch,R. H.; Heeres,H. J.
    参考文献:Biomass And Bioenergy 日期:2020 卷标:134]

    = 645-56-7 + 2380-78-1 + 93-51-6 + 831-00-5 + 90-05-1 + 61292-90-8 + 60563-13-5 + 5597-50-2
    反应条件:1.1 Catalysts: Ruthenium,Carbon Solvents: Ethanol; 100 °C
    标题:Antimicrobial Properties Of Corn Stover Lignin Fractions Derived From Catalytic Transfer Hydrogenolysis In Supercritical Ethanol With A Ru/c Catalyst
    作者:Kalinoski,Ryan M.; Et Al
    参考文献:Acs Sustainable Chemistry & Engineering 日期:2020 卷标:8(50) 页码:18455-18467]

    = 645-56-7 + 97-54-1 + 831-00-5 + 90-05-1 + 3468-99-3 + 19037-58-2 + 61292-90-8 + 60563-13-5 + 134-96-3 + 2478-38-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Platinum Solvents: Ethanol; 4 H,250 °C
    标题:Lignin Depolymerization: A Comparison Of Methods To Analyze Monomers And Oligomers
    作者:Bartolomei,Erika; Et Al
    参考文献:Chemsuschem 日期:2020 卷标:13(17) 页码:4633-4648
茴香烯置于镍体系中,50.0 °C,12.75 Mpa 条件下,反应生成 4-丙基苯酚
参考文献:The Isomeric 4-N-Propylcyclohexanols1
标题:The Isomeric 4-N-Propylcyclohexanols1
摘要:
DOI:10.1021/jo01182A004

海关参考信息

专利信息


专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-6252092-B1
优先权日:1999-04-30
标 题 :Process for synthesis of 5-alkylbenzodioxoles
发明人:BORZATTA VALERIO; BRANCALEONI DARIO; BATTISTINI CHRISTIAN
权利人:ENDURA SPA
摘要:The following description refers to a new process for the synthesis of 5-alkylated benzo[1,3]dioxole, comprising the following steps in sequence: catalytic hydrogenation of 4-acylphenol; acylation; displacement catalysed by Lewis acids; treatment with an inorganic basic compound and hydrogen peroxide; reaction with alkyl dihalides or dialkoxyalkanes. n The process described herein, which yields 5-alkylbenzo[1,3]dioxoles, is economic and can be easily scaled up to industrial size.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人:TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-9783642-B1
优先权日:2016-04-12
标题 :Difunctional polyhedral oligomeric silsesquioxane derivative and synthesis thereof
发明人:LIN YUNG-CHIH; KUO SHIAO-WEI
权利人:NAT SUN YAT-SEN UNIV
摘要:A difunctional polyhedral oligomeric silsesquioxane derivative and synthesis of the present invention is disclosed. The difunctional polyhedral oligomeric silsesquioxane derivative is represented by following formula (I), wherein R is selected from one of n nandn n nThe synthesis of the difunctional polyhedral oligomeric silsesquioxane derivative includes obtaining bis-PA-DDSQ compound though addition reaction of DDSQ compound and 4-acetoxystyrene, obtaining bis-Ph-DDSQ compound though hydrolytic reaction of bis-PA-DDSQ compound and hydrazine, and obtaining bis-AlBz-DDSQ compound though cycloaddition reaction of bis-Ph-DDSQ compound and paraformaldehyde.

专利号:US-2006154325-A1
优先权日:2005-01-10
标题 :Synthesis of epoxide based inhibitors of cysteine proteases
发明人:BOGYO MATTHEW; VERHELST STEVEN H
权利人:BOGYO MATTHEW; VERHELST STEVEN H
摘要:Epoxide based cysteine protease inhibitors containing peptide derivatives and methods for synthesizing them in sold phase are disclosed. Preferably, an epoxy succinyl “warheadâ€? (for binding to the enzyme) is prepared, having two amino acid residues or residue-like structures on either side. Natural and non-natural amino acids may be used. The present process may be carried out entirely on a solid support, with the proviso that a dipeptide like group is prepared prior to coupling to one side of the supported complex. The method lends itself to more efficient inhibitor synthesis, and may be employed with mixtures of peptide compounds, and various modifications of epoxides to create diverse libraries of inhibitors.
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主要参考文献

[参考文献]: Alfonso Pérez-Garrido, Et Al. Convenient Qsar Model For Predicting The Complexation Of Structurally Diverse Compounds With Beta-Cyclodextrins. Bioorg Med Chem. 2009 Jan 15;17(2):896-904.
[参考文献]: Cynthia D Selassie, Et Al. Cellular Apoptosis And Cytotoxicity Of Phenolic Compounds: A Quantitative Structure-Activity Relationship Study. J Med Chem. 2005 Nov 17;48(23):7234-42.
[参考文献]: Isabella Karlsson, Et Al. Investigation Of The Sunscreen Octocrylene'S Interaction With Amino Acid Analogs In The Presence Of Uv Radiation. Photochem Photobiol. 2012 Jul-Aug;88(4):904-12.
[参考文献]: Shosuke Ito, Et Al. A Convenient Screening Method To Differentiate Phenolic Skin Whitening Tyrosinase Inhibitors From Leukoderma-Inducing Phenols. J Dermatol Sci. 2015 Oct;80(1):18-24.

合成参考文献


摘要:Ewing, T. A.; Fraaije, M. W.; van Berkel, W. J. H., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 165.
摘要:Dai, X.; Shi, F., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 148.
摘要:Journal of Medicinal Chemistry., 18(868), 1975
摘要:P. Demerseman, J. P. Lechartier, R. Reynaud, A. Cheutin, R. Royer and P. Rumpf, Bull. Soc. Chim. Fr. 1963, 2559.
摘要:Angelini, E.; Sarlah, D., Science of Synthesis: Dearomatizations, (2026) .
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