CAS: 6188-25-6; 6-Chloroimidazo[1,2-A]Pyridine

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CAS号107-20-0 一氯乙醛 | CAS号5350-93-6 2-氯-5-氨基吡啶 | CAS号886371-28-4 3-溴-6-氯咪唑并[1,2-a]吡啶

氯乙醛,2-氨基-5-氯吡啶 以 乙醇 作为反应溶剂,化学反应生成 6-氯咪唑并[1,2-A]吡啶
参考文献:从合成的简化海洋代谢物类似物到新的极光b激酶选择性变构抑制剂
标题:从合成的简化海洋代谢物类似物到新的极光b激酶选择性变构抑制剂
摘要:通过合成属于海绵的海洋吡咯-2-氨基咪唑代谢产物的苯并ceptors和oroidin的简化片段,可以实现对aurora B的显着抑制.激酶抑制作用的评估使得能够发现可合成获得的刚性炔属结构类似物el-228(1),其结构可以优化为有效的cj2-150(37).在这里,我们介绍了新的aurora B激酶抑制剂的合成,该抑制剂是通过有丝分裂调节进行癌症治疗的重要靶标.生物定向合成产生了几种纳摩尔抑制剂.优化的化合物cj2-150(37)在aurora B激酶的混合型抑制中显示了非atp竞争性变构作用模式.分子对接在变构位点" F"中确定了可能的结合模式,并强调了与蛋白质的关键相互作用.我们描述了新型支架的抑制力和特异性的提高以及作用机理的表征.
DOI:10.1021/acs.Jmedchem.0C02064

专利信息

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides

专利号:EP-1600452-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides

专利号:EP-1634888-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides

专利号:EP-1232166-A2
优先权日:1999-11-12
标 题:Synthesis of 2'-deoxy-l-nucleosides