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专利信息
专利号:US-2019134188-A1
优先权日:2016-02-24
标题:Recombinant Newcastle Disease Virus Expressing an Immunomodulatory Protein as a Molecular Adiuvant
发明人:ABSALÓN CONSTANTINO ANGEL EDUARDO; CORTÉS ESPINOSA DIANA VERÓNICA; GALIOTE FLORES ALEJANDRA; LUCIO DECANINI EDUARDO; TOSCANO CONTRERAS ARNULFO
权利人:INVESTIG APLICADA S A DE C V
摘要:The present invention refers to recombinant Newcastle disease viruses (rNDV) having inserted a transcriptional unit foreign to its genome, which codifies for the synthesis of immunomodulatory proteins. These systems provide excellent protection results and significantly reduce the excreted viral load (post-vaccination and post-challenge) in poultry immunized several weeks after being challenged with a velogenic strain of the Newcastle virus. Additionally, said vaccines allow for the protection of poultry against other pathogenic agents during a long time period as they induce an increase of the immunomodulatory proteins level, which results in an enhancement of the immune response of the host and the development of an efficient humoral and cellular response.
专利号:US-2005090545-A1
优先权日:2003-10-22
标题:Nitric oxide topical technology
发明人:LEITMAN LORN; BARNI GUSTAVO
摘要:This invention with a new compound enables application of L-Arginine made with arginine alpha-ketoglutarate, arginine pyroglutamate, arginine ketoisocaproate and ornithine alpha-ketoglutarate to work together and separately along with other ingredients, topically. It is intended to improve the process by which these compounds work in the human organism. The invention is based on the facts that L-Arginine is: known to be the immediate precursor of the endogenous vasodilator substance found in the arterial blood vessels called “Endothelium-Derived Relaxing Factorâ€? (EDRF) required for protein synthesis and, depending on the organism's needs, can either be metabolized to support glucose synthesis or catabolized to produce energy This simplified “noninvasiveâ€? application surpasses gastrointestinal digestion so the compounds will not degrade and favoring absorption into the circulatory system thus enhancing the compounds' effects and at much lower dosage levels than oral or parenteral administration. A composition comprising L-Arginine to be used topically that creates increases in muscle size, strength, endurance andpower output.
专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人:FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.