CAS: 54125-02-9; (E)-((4-Methoxybuta-1,3-Dien-2-yl)Oxy)Trimethylsilane

该化合物是一种专门的有机硅化合物,用于有机合成,特别是用于理顺和交叉组合反应,其主要优势包括它作为酒精和苯酚的多用途保护组的作用,在各种反应条件下提供稳定性,同时允许有选择的去保护.该化合物的甲基氧和三甲基环球体组加强了其在核分裂和电生殖转化中的回弹性,使其在复杂分子合成中具有价值.其结构特征也促进了受控聚合过程.该产品的特点是高度纯度和连续性能,确保研究和工业应用的再生性.建议在惰性条件下进行适当处理以保持其稳定性.

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38053-91-7 1833-53-0

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CAS号75-77-4 三甲基氯硅烷 | CAS号51731-17-0 反式-4-甲氧基-3-丁烯-2-酮 | CAS号27607-77-8 三氟甲磺酸三甲基硅酯 | CAS号3722-51-8 3-羟基-9H-占吨-9-酮 | CAS号605-55-0 2-菲醇 | CAS号605-87-8 3-菲醇 | CAS号4652-27-1 4-甲氧基-3-丁烯-2-酮 | CAS号13623-25-1 6-甲氧基-1-茚满酮 | CAS号5111-70-6 5-甲氧基-1-茚酮 | CAS号3470-49-3 5-羟基-1-茚酮 | CAS号62803-47-8 6-羟基-1-茚酮

合成工艺路线路线简述

  • 合成目标产物 1-Methoxy-3-Trimethylsiloxy-1,3-Butadiene 主要起始原料 Chlorotrimethylsilane And 4-Methoxy-3-Buten-2-One
  • (文献来源)合成步骤主要原料 Chlorotrimethylsilane 和 4-Methoxy-3-Buten-2-One
📜三甲基氯硅烷,4-Methoxy-3-Buten-2-One置于三乙胺,Zinc(II) Chloride体系中,化学反应生成 反-1-甲氧基-3-(三甲基硅氧基)-1,3-丁二烯
参考文献:Useful Diene For The Diels-Alder Reaction
标题:Useful Diene For The Diels-Alder Reaction
摘要:
DOI:10.1021/ja00832A031

海关参考信息

专利信息


专利号:US-5597931-A
优先权日:1992-03-30
标 题:Total synthesis of taxol and analogues thereof
发明人:DANISHEFSKY SAMUEL J; MASTERS JOHN; YOUNG WENDY; LINK J THOMAS; ISAACS RICHARD; SNYDER LAWRENCE B
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

专利号:US-5488116-A
优先权日:1992-03-30
标 题:Total synthesis of taxol and analogues thereof
发明人:DANISHEFSKY SAMUEL J; BORNMANN WILLIAM G; QUENEAU YVES; MAGEE THOMAS V; KROL WALTER J; MASTERS JOHN J; JUNG DAVID K
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

专利号:US-5527924-A
优先权日:1992-03-30
标题 :Total synthesis of taxol
发明人:DANISHEFSKY SAMUEL J; BORNMANN WILLIAM G; QUENEAU YVES; MAGEE THOMAS V; KROL WALTER J
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides two basic routes for the total synthesis of taxol having the structure: The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.

专利号:US-2018111889-A1
优先权日:2015-03-20
标 题:Methods of making multicyclic compounds using multicomponent/tandem reaction sequences
发明人:CHALIFOUX WESLEY A; CARMICHAEL RACHAEL A
权利人:BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA
摘要:Disclosed herein are embodiments of multicyclic compounds and methods of making such compounds. The disclosed methods reduce step-counts in the synthesis of complex targets, while reducing costs and waste streams.

专利号:WO-9946267-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人:MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Marie-Laure Teyssot, Et Al. Cross-Diels-Alder Reactions Of 6-Oxo-1-Sulfonyl-1,6-Dihydropyridine-3-Carboxylates. J Org Chem. 2007 Mar 30;72(7):2364-73.
[参考文献]: Mingji Dai, Et Al. Highly Selective Diels-Alder Reactions Of Directly Connected Enyne Dienophiles. J Am Chem Soc. 2007 Jan 24;129(3):645-57.
[参考文献]: Orazio A Attanasi, Et Al. Flexible Protocol For The Chemo- And Regioselective Building Of Pyrroles And Pyrazoles By Reactions Of Danishefsky'S Dienes With 1,2-Diaza-1,3-Butadienes. Org Lett. 2008 May 15;10(10):1983-6.

合成参考文献


摘要:Shindo, M.; Yoshikawa, T.; Yaji, K., Science of Synthesis, (2009) 46, 389.
摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 651.
摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 585.
摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 641.
摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 655.
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