CAS: 529-69-1; 2-Aminopteridine-4,7(1H,8H)-Dione

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CAS号3254-85-1 2-amino-4,7-dio... | CAS号2577-38-0 2,4,7(1H,3H,8H)... | CAS号2817-14-3 2,4,6,7(1H,3H)-...

📜(2,4-Diamino-6-Oxo-1,6-Dihydro-Pyrimidin-5-Ylimino)-Acetic Acid Ethyl Ester置于ammonium Hydroxide体系中,化学反应生成 异黄蝶呤
参考文献:Albert; Wood,Journal Of Applied Chemistry,1953,Vol. 3,P. 521
标题:Albert; Wood,Journal Of Applied Chemistry,1953,Vol. 3,P. 521

专利信息

专利号:US-6153615-A
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobioterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonists are administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylactic or curative effect for endotoxin- or cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension). The tetrahydrobiopterin synthesis antagonist may be administered with α 1 -adrenergic agonist or with nitric oxide synthase inhibitor. The tetrahydrobiopterin synthesis antagonists are also administered to attenuate inflammation caused by induced nitric oxide production in immune cells. Unwanted counterproductive or side effects can be eliminated or ameliorated by administration additionally of levodopa with or without carbidopa and L-5-hydroxytryptophane.

专利号:US-12428442-B2
优先权日:2017-06-21
标题 :Compounds, compositions and methods for synthesis
发明人：BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
权利人:WAVE LIFE SCIENCES LTD
摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

专利号:US-6274581-B1
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonist are administered to inhibit nitric oxide synthesis from arginine in vascular smooth muscle cells in a subject in need of such inhibition (e.g. for prophylactic or curative effect for cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension).

专利号:US-6844343-B1
优先权日:1999-09-17
标 题 :N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
发明人：PFLEIDERER WOLFGANG; SCHMIDT HARALD; FROEHLICH LOTHAR; KOTSONIS PETER; TAGHAVI-MOGHADAM SHAHRIYAR
权利人:VASOPHARM BIOTECH GMBH
摘要:Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R<1 >and R<2>=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R<3>=H, -CO-Alkyl, or -CO-Aryl, R<4>=Aryl, -CO-O-Aryl or -CO-Aryl and R<5>=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.

专利号:JP-6490133-B2
优先权日:2011-07-19
标 题 :Methods for the synthesis of functionalized nucleic acids

专利号:US-5612468-A
优先权日:1994-05-18
标题:Pteridine nucletide analogs as fluorescent DNA probes
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; DAVIS MICHAEL D; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.