CAS: 52663-74-8; 2,2',3,3',4,5,5'-Heptachlorobiphenyl

该化合物是多氯代氯联苯(PCB)家族的成员,由多氯替代物组成的双联苯分子组成,其特点是氯化程度高,增强了其疏水性和稳定性,使其耐受环境降解的影响,七氯联二苯一般在室温下是固体,具有低挥发性,其化学结构助长了其亲脂性,导致活生物体中的生物体生物累积和潜在毒性.该化合物因其环境持久性和潜在健康影响,包括内分泌干扰和致癌性而进行了研究.由于这些关切,许多国家对多氯联苯的使用,包括七氯代苯的使用实行了严格的管制或禁止.通常使用气体色谱-质谱仪(GC-MS)等分析方法,在环境样本中检测和量化该物质.总体而言,2,3,3欧元,3万欧元,4,5,5欧元-七氯二苯是氯化有机化合物对环境和健康构成挑战的重要例子.

英文名称2,2',3,3',4,5,5'-Heptachlorobiphenyl
中文名称2,2',3,3',4,5,5'-七氯联苯
IUPAC名称1,2,3,4-tetrachloro-5-(2,3,5-trichlorophenyl)benzene
其它别名2,2',3,3',4,5,5'-Heptachloro-1,1'-biphenyl; 2,2',3,3',4,5,5'-Heptachlorobiphenyl; 2,3,5,2',3',4',5'-Heptachlorobiphenyl
CAS编号52663-74-8
MFCD编号:MFCD00792631
FDA UNII编号:5MUM06YX8G
分子式:C12H3Cl7分子量:395.32
产品CID: 2496362
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: HOPMUCXYRNOABF-UHFFFAOYSA-N
1S/C12H3Cl7/c13-4-1-5(9(16)7(14)2-4)6-3-8(15)11(18)12(19)10(6)17/h1-3H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4,5-tetrachloroaniline 1,2,4-Trichlorobenzene

合成工艺路线路线简述

📜2,3,4,5-四氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,3',4,5,5'-七氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4