CAS: 524-17-4; 4-(((R)-6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-1-yl)Methyl)-2-(4-(((R)-6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-1-yl)Methyl)Phenoxy)Phenol

该化合物是来自诸如 * Menispermum dauricum* 等植物的双苯基汞碱, 展示了显著的生物活动, 包括抗体操, 抗血压和潜在的抗突触特性. 它的机制包括钙管阻塞和细胞信号路径的调制. Dauricine因其结构复杂性和治疗潜力而在药理学研究中受到重视.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

合成工艺路线路线简述

    📜反应生成 蝙蝠葛碱
    参考文献:Tetrahedron Letters 1964,58,2771-2775
    标题:Tetrahedron Letters 1964,58,2771-2775

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    专利信息


    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis

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    合成参考文献


    摘要:He L, Liu GQ. Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier. Acta Pharmacol Sin. 2002 May;23(5):423–9.
    参考文献:10.1007/s11011-017-9963-x
    摘要:Rajput MA, Khan RA. Phytochemical screening, acute toxicity, anxiolytic and antidepressant activities of the Nelumbo nucifera fruit. Metab Brain Dis. 2017 Jun;32(3):743–9. doi: 10.1007/s11011-017-9963-x.
    参考文献:10.1007/bf02253669|10.1159/000025413
    摘要:Su MJ, Chen WP, Lo TY, Wu TS. Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart. J Biomed Sci. 1999 Nov;6(6):376–86. doi: 10.1007/bf02253669.
    参考文献:10.1097/00007890-199911150-00027
    摘要:Lai JH, Ho LJ, Kwan CY, Chang DM, Lee TC. Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology. Transplantation. 1999 Nov 15;68(9):1383–92. doi: 10.1097/00007890-199911150-00027.
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