CAS: 52-86-8; 4-[4-(4-Chlorophenyl)-4-Hydroxy-1-Piperidinyl]-1-(4-Fluorophenyl)-1-Butanone

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CAS号150717-69-4 4-(4-chlorophen... | CAS号39512-49-7 4-(4-氯苯基)-4-羟基哌啶 | CAS号3874-54-2 4-氯-4'-氟苯丁酮 | CAS号56660-99-2 4-(p-Chlorophen... | CAS号34104-67-1 还原氟哌啶醇 | CAS号1183278-95-6 1-(4-chlorobut-... | CAS号39560-31-1 4-(4-氟苯基)-4-氧代丁酸甲酯 | CAS号847025-06-3 3-[2-(4-fluorop... | CAS号847025-05-2 3-[2-(4-fluorop... | CAS号3308-94-9 2-(3-氯丙基)-2-(4-... | CAS号34104-67-1 还原氟哌啶醇 | CAS号459-57-4 对氟苯甲醛 | CAS号403-42-9 对氟苯乙酮 | CAS号61668-02-8 1-(4-fluorophen... | CAS号108-90-7 氯苯 | CAS号107-02-8 丙烯醛

3-[2-(4-Fluorophenyl)-[1,3]Dioxolan-2-Yl]Propionic Acid Methyl Ester置于盐酸,二异丁基氢化铝,Sodium Cyanoborohydride,溶剂黄146体系中,用 四氢呋喃,甲醇,二氯甲烷 作为反应溶剂,化学反应 33.0H,反应生成 氟哌啶醇
参考文献:室温离子液体中的stetter反应及其在氟哌啶醇合成中的应用
标题:室温离子液体中的stetter反应及其在氟哌啶醇合成中的应用
摘要:咪唑型室温离子液体(rtil)已用于stetter反应,以非常好的收率提供了所需的1,4-二羰基化合物.噻唑鎓盐和et 3 N是在离子液体中进行该反应的有效催化剂.已经证明了再循环和再利用溶剂的可能性,尽管不可能再循环噻唑鎓催化剂.该方法用于氟哌啶醇的全合成.
DOI:10.1002/adsc.200404123

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:EP-2960302-A1
优先权日:2014-06-26
标题 :Method of synthesis of hybrid compounds of polyaniline and application of hybrid compounds of polyaniline
发明人：SZYMANSKI WOJCIECH; HALAMA AGNIESZKA; MADALINSKI JACEK; PASCIAK GRZEGORZ
权利人:INST ELEKTROTECHNIKI
摘要:The subject of this invention is a method of synthesis of of hybrid compounds of polyaniline and application of hybrid compounds of polyaniline. n The method consists in that to an ice water cooled acid solution, selected from the group of orthophosphoric acids of a concentration of 0.1 - 6 M, or hydrochloric, hydrofluoric, nitric and sulfuric acid of a concentration 0.1 - 8 M, containing an oxidizer in a form of dissolved ammonium persulfate (NH 4 ) 2 S 2 O 8 in the amount of 10.0 - 20.0 g and 5.0 - 20.0 g of ammonium heptamolybdate tetrahydrate (NH 4 ) 6 Mo 7 O 24 x 4 H 2 O), 5.11 g of aniline is added, whereby the cooled solution is stirred for at least 1 hour, and then left for at least 4 hours at an ambient temperature, and after sedimentation the dark-green precipitate of polyaniline heptarilolybdate is filtered, thoroughly rinsed with distilled water until the filtrate is colorless and finally dried at 378 K for at least 8 hours. Application consists in that the polyaniline heptamolybdates, added in the amount of 0.1 to 5 mass %, play a role of inhibitors, enhancing corrosion resistance of coatings made from epoxy resins, water soluble polyvinyl, acryl and alkyd epoxy paints, and paints dissolved in two-component solvents.

专利号:EP-2465936-A1
优先权日:2010-12-20
标题 :Enzymatic synthesis of statins and intermediates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.

专利号:US-2022298522-A1
优先权日:2019-07-30
标 题:Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
发明人：FLAISHMAN MOSHE ARIE; SHAFRAN-TOMER HADAS; COHEN PEER REUT; COHEN ODED
权利人:THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION
摘要:A method of controlling cannabinoid synthesis in a cell or plant or plant part comprising same is provided. The method comprising modulating expression in the cell of at least one polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO: 1-15 and 18-86, the polypeptide modulating cannabinoid synthesis, thereby controlling cannabinoid synthesis in the cell. Also provided are methods of producing cannabinoids and selecting plants producing cannabinoids of interest.