CAS: 519-32-4; 1,3,9-Trimethyl-3,9-Dihydro-1H-Purine-2,6-Dione

上下游产品

diazomethane 9-methylxanthine 5-amino-1,3-dimethyl-6-methylaminopyrimidine-2,4(1H,3H)-dione formamide1,3,9-trimethyluric acid [(NH3)5RuTMX][ZnCl4]Cl

📜茶碱置于sodium Hydride,三乙胺体系中,用 N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 4.0H,反应生成 1,3,9-三甲基黄嘌呤
参考文献:Hori,Mikio; Kataoka,Tadashi; Shimizu,Hiroshi,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 3,P. 1328-1332
标题:Hori,Mikio; Kataoka,Tadashi; Shimizu,Hiroshi,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 3,P. 1328-1332

专利信息

专利号:US-7820810-B2
优先权日:2007-03-19
标 题 :Process for the synthesis of 2′-O-substituted purine nulceosides
发明人：RAVIKUMAR VASULINGA
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention provides an improved process for the synthesis of 2′-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2′-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis acid ester, followed by reduction to afford the desired 2′-O-substituted purine nucleoside.

专利号:US-5955083-A
优先权日:1996-01-03
标 题 :Use of eriobotrya japonica extract, in particular in cosmetics for stimulating glycosaminoglycan synthesis
发明人：BONTE FREDERIC; DUMAS MARC
权利人:LVMH RECH
摘要:PCT No. PCT/FR97/00009 Sec. 371 Date Aug. 28, 1997 Sec. 102(e) Date Aug. 28, 1997 PCT Filed Jan. 3, 1997 PCT Pub. No. WO97/06659 PCT Pub. Date Feb. 27, 1997The invention concerns novel uses of an Eriobotrya japonica extract, in particular in cosmetics or pharmaceutics. This extract permits stimulation of glycosaminoglycan synthesis, in particular of hyaluronic acid, thus imparting to the cosmetic compositions containing this extract the properties of improving the firmness and suppleness of the skin, combating the formation of wrinkles or lessening the depth thereof, smoothing the surface of the skin by means of a tightening effect, or moisturizing the skin. The invention further concerns the use of these extracts for stimulating the synthesis of glycosaminoglycans from a cell culture medium, in particular fibroblasts or keratinocytes.

专利号:US-2005089893-A1
优先权日:2003-08-06
标题:Methods and compositions for in vitro and in vivo use of parallel stranded hairpins and triplex structures as nucleic acid ligands
发明人：LOPEZ MARTIN J; MUNZER MARTIN; ERITJA RAMON
摘要:The invention sets forth parallel-stranded hairpins and parallel-stranded hairpins carrying a single strand target, the parallel-stranded hairpins containing 8-aminopurine residues and are able to bind a target molecule of interest due to specificity in the two-dimensional and three-dimensional structures of the parallel-stranded hairpins and parallel-stranded hairpins carrying a single strand target. The invention also relates to creation of a library of parallel-stranded hairpins and associated triplexes for use as aptamers, as well as methods of synthesis of parallel-stranded hairpins and use of the structures of the invention to detect and eliminate molecules of interest.

专利号:US-11412771-B2
优先权日:2019-04-12
标题 :Composition to improve athletic performance by supporting muscle protein synthesis and mental focus
发明人：WOLFE ROBERT REESE; WOLFE FREDERICK LEE
权利人:The Amino Company LLC
摘要:The present invention generally relates to compositions and methods for supporting exercise performance or activities of daily living. The compositions described herein are pharmaceutical or nutritional compositions suitable for enhancing exercise performance. The compositions are based on a specially formulated mixture of essential amino acids (EAAs) with additional components. The compositions target support of muscle protein synthesis and reduction of muscle breakdown during exercise, increasing muscle blood flow during exercise, decreasing the perception of fatigue by supporting optimal availability of neurotransmitter precursors, providing energy for rapids bursts of exertion during exercise, and maintaining adequate electrolyte balance during exercise.

专利号:US-8865116-B2
优先权日:2012-03-20
标题:Method for preparation of hematite iron oxide with different nanostructures and hematite iron oxide prepared thereby
发明人：YU JONG-SUNG; CHAUDHARI NITIN KADUBA; KIM HYOUNG CHAN; KIM CHUL SUNG; PARK JEUNGHEE
权利人:UNIV KOREA RES & BUS FOUND
摘要:Disclosed is a method for preparing hematite iron oxide having various nanostructures, including: preparing a mixture solution by adding iron chloride and caffeine to a solvent and magnetically stirring; and performing hydrothermal synthesis, wherein the solvent is selected from water, ethanol, propanol and methanol. In accordance with the present disclosure, hematite iron oxide (α-Fe 2 O 3 ) superstructures of various shapes, including grape, cube, dumbbell and microsphere shapes, can be synthesized in different solvents using caffeine. The shapes can be controlled variously via a simple one-step synthesis route without using a growth-inducing agent and without separation based on size. The prepared hematite iron oxide exhibits high coercivity at room temperature owing to its fine crystal structures and anisotropic shapes. The hematite iron oxide nanoparticles having different nanostructures prepared according to the present disclosure may be widely useful in biological and biochemical applications as a material having peroxidase mimic activity and thus capable of replacing natural enzymes.

专利号:US-6180133-B1
优先权日:1997-11-25
标 题 :Antioxidant composition for topical/transdermal prevention and treatment of wrinkles
发明人：QUAN DANYI; VENKATESHWARAN SRINIVASAN; EBERT CHARLES D
权利人:WATSON PHARMACEUTICALS INC
摘要:An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.