📜氯代叔丁烷 反应生成 叔丁基磷酸 参考文献:Murav'Ev,I.V.; Fedorovich,I.S.,Journal Of General Chemistry Of The Ussr,1975,Vol. 45,P. 1711-1713 标题:Murav'Ev,I.V.; Fedorovich,I.S.,Journal Of General Chemistry Of The Ussr,1975,Vol. 45,P. 1711-1713
专利信息
专利号:US-12037636-B2 优先权日:2018-07-19 标题 :Polynucleotide synthesis method, kit and system 发明人:MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE 权利人:OXFORD NANOPORE TECH PLC 摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
专利号:US-2017029451-A1 优先权日:2013-12-05 标 题:Branched chain acyclic nucleoside phosphonate esters and methods of synthesis and uses thereof 发明人:WARE ROY W; DOWNEY AARON L; LANIER ERNEST RANDALL; SETHNA PHIROZE; SELLESETH DEAN 权利人:CHIMERIX INC 摘要:The present invention is directed to branched chain nucleoside phosphonate ester compounds and methods of synthesis thereof. The present invention is also directed to pharmaceutical compositions comprising branched chain nucleoside phosphonate ester compounds and methods of treating and/or preventing double stranded DNA viral infection and/or viral infection associated disease or disorder.
专利号:US-9982006-B2 优先权日:2014-08-21 标题:2′-chloro aminopyrimidinone and pyrimidine dione nucleosides 发明人:CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN 权利人:GILEAD SCIENCES INC 摘要:Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.
专利号:US-7511113-B2 优先权日:2002-04-26 标题:Oligomeric hydroxy arylether phthalonitiles and synthesis thereof 发明人:KELLER TEDDY M; DOMINGUEZ DAWN D 权利人:US NAVY 摘要:An aromatic ether oligomer or polyaromatic ether comprising the formula:n n O—Ar n ;n nwherein Ar is an independently selected divalent aromatic radical; formed by reacting a dihydroxyaromatic with a dihaloaromatic; and wherein the reaction is performed in the presence of a copper compound and cesium carbonate. The polyaromatic ether is formed when neither the dihydroxyaromatic nor the dihaloaromatic is present in an excess amount. The aromatic ether oligomer is formed by using an excess of either dihydroxyaromatic or dihaloaromatic. A phthalonitrile monomer comprising the formula:n n nformed by reacting a 3- or 4-nitrophthalonitrile with a hydroxy-terminated aromatic ether oligomer. A thermoset formed by curing the phthalonitrile monomer. Processes for forming all the above.
专利号:US-9828388-B2 优先权日:2014-07-28 标题:Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections 发明人:CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN 权利人:GILEAD SCIENCES INC 摘要:Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.
专利号:US-9701682-B2 优先权日:2013-11-11 标题:Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections 发明人:CLARKE MICHAEL O'NEIL HANRAHAN; DOERFFLER EDWARD; MACKMAN RICHARD L; SIEGEL DUSTIN 权利人:GILEAD SCIENCES INC 摘要:Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.
[参考文献]: Dipankar Sahoo, Et Al. Di-, Tri- And Tetranuclear Molecular Vanadium Phosphonates: A Chloride Encapsulated Tetranuclear Bowl. Dalton Trans. 2014 Jul 28;43(28):10898-909. [参考文献]: Justus Tnnemann, Et Al. Borophosphonate Cages: Easily Accessible And Constitutionally Dynamic Heterocubane Scaffolds. Chemistry. 2012 Aug 6;18(32):9939-45. [参考文献]: Saskia Speed, Et Al. Hexanuclear Copper(Ii) Cages Built On A Central {μ3-O···h···μ3-O} Moiety, 1,3-Bis(Dimethylamino)-2-Propanolato And Capping R-Phosphonates: Crystal Structures, Magnetic Behavior, And Dft Studies. Inorg Chem. 2012 Jun 18;51(12):6842-50. [参考文献]: Vadapalli Chandrasekhar, Et Al. Multicomponent Assembly Of Anionic And Neutral Decanuclear Copper(Ii) Phosphonate Cages. Inorg Chem. 2012 May 21;51(10):5605-16.
合成参考文献
参考文献:10.1021/ac035072y 摘要:Zhou Y, Yu B, Shiu E, Levon K. Potentiometric sensing of chemical warfare agents: surface imprinted polymer integrated with an indium tin oxide electrode. Anal Chem. 2004 May 15;76(10):2689–93. doi: 10.1021/ac035072y. 参考文献:10.1021/ic701343s 摘要:Wang M, Ma CB, Yuan DQ, Wang HS, Chen CN, Liu QT. Synthesis and characterization of a family of penta- and tetra-manganese(III) complexes derived from an assembly system containing tert-butylphosphonic acid. Inorg Chem. 2008 Jul 07;47(13):5580–90. doi: 10.1021/ic701343s.