CAS: 39226-95-4; 2,3-Dichlorobenzylamine

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CAS号6574-97-6 2,3-二氯苯腈 | CAS号32768-54-0 2,3-二氯甲苯

2,3-二氯苯腈置于indium(III) Chloride,Sodium Tetrahydroborate体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以75%的收率获得2,3-二氯苄胺
参考文献:Incl 3与各种还原剂的反应:Incl 3-Nabh 4介导的芳香族和脂肪族腈还原为伯胺
标题:Incl 3与各种还原剂的反应:Incl 3-Nabh 4介导的芳香族和脂肪族腈还原为伯胺
摘要:虽然探索了使用氨基硼氢化锂(lab )通过原位还原incl 3制备二氯氢化铟(hincl 2)的替代方法,但硼氢化钠(nabh 4)还原incl 3产生hincl 2的方法也得到了重新进行比较评估.发现incl 3 / Nabh 4系统的还原能力高度依赖于所用溶剂.通过11 B NMR光谱分析的研究表明,Incl 3与nabh 4在thf中的反应生成hincl 2以及硼烷-四氢呋喃(bh 3.thf)原位.在25oc的最佳条件下,使用1当量的无水incl 3和3当量的nabh 4在thf中,将腈还原为伯胺.各种芳香族,杂芳香族和脂肪族腈以70-99%的分离产率还原为相应的伯胺.通过一锅反应利用hincl 2和bh 3 .thf的还原能力,烷基卤化物和腈官能团被串联还原.最终,在腈存在下,通过在ch 3中用nabh 4还原incl 3生成hincl 2,实现了对碳溴键的选择性还原.Cn或二甲
Doi:10.1021/jo201809A

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:CN-119140080-A
优先权日:2024-11-14
标题 :A titanium oxide film catalytic material for rapid and high-yield synthesis of imines, and preparation method and use thereof

专利号:CN-119140080-B
优先权日:2024-11-14
标 题 :Titanium oxide film catalytic material for rapid high-yield synthesis of imine and preparation method and application thereof