CAS: 25999-31-9; Lasalocid
该化合物是一种聚醚离子体抗生素,主要用作牲畜饲料添加剂,以促进生长和预防影响家禽和其他动物的寄生虫病 ----寄生虫病 ----影响家禽和其他动物的寄生虫病 ----发酵产物,其产物为细菌发酵过程的土壤发酵过程,该复合体具有独特的结构,其特点是环球聚醚框架,它能够形成复合物,特别是钠和钾离子,便利其跨生物膜的运输.Lasalocid A因其能够破坏离子梯度,导致目标生物细胞功能的改变而闻名.除了其兽医应用外,还研究其对人类健康的潜在影响及其因动物废物的持久性而对环境造成的影响.该物质通常在动物饲料中低浓度地施用,许多国家对其使用加以管制,以确保安全和效率.与其他离子素一样,必须谨慎管理,以减轻病原体抗性抗力发展的风险.
- 英文名称Lasalocid
- 中文名称那塞罗
- IUPAC名称6-((3R,4S,5S,7R)-7-((2S,3S,5S)-5-ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-3-methyltetrahydrofuran-2-yl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-2-hydroxy-3-methylbenzoic acid
- 其它别名Lasal°Cid; [2R-[2alpha[2S*(3R*,4S*,5S*,7R*)3S*,5S*],5alpha,6beta]]-6-[7-[5-ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-3-methylsalicylic acid; Benzoic acid, 6-(3R,4S,5S,7R)-7-(2S,3S,5S)-5-ethyl-5-(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yltetrahydro-3-methyl-2-furanyl-4-hydroxy-3,5-dimethyl-6-oxononyl-2-hydroxy-3-methyl-; Lasal°Cid A; 6-{7-[(5S)-5-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-5-ethyl-3-methyloxolan-2-yl](4S,5S,3R,7R)-4-hydroxy-3,5-dimethyl-6-oxononyl}-2-hydroxy-3-methylbenzoic acid
- CAS编号25999-31-9
- MFCD编号:MFCD00242774
- EINECS号:247-401-9
- 分子式:C34H54O8分子量:590.79
- 产品CID: 1227474
- 同类组份化合物CAS73951-77-6 (acetate),62211-64-7 (anion)25999-31-9 (free acid)25999-20-6 (sodium)83198-76-9 (potassium)
- 产品分类化学农药原药 → 杀菌剂
物理性质
- 熔点110-114°; mp 100-109° (unsharp)
- 沸点735.7±60.0 °C at 760 mmHg
- 闪点224.8±26.4 °C
- 密度1.1±0.1 g/cm3
- PH:D25 -7.55° (methanol)
- pKa:3.15±0.39(预测)
- PSA:133.52
- LogP:6.55
- 折射率1.529
- 蒸汽压0.0±2.5 mmHg at 25°C
- 溶解性Acetonitrile,(Slightly), Methanol (Slightly, Sonicated)
- 外观形态白色至类白色固体
- 储存条件-20°C 冰箱, 在惰性气其中
- 产品应用该化合物用于治疗脑肿瘤的聚醚抗生素组成,还抑制了脑膜球体GPD2活动,并对癌症细胞产生抗扩散影响.
上下游产品
CAS号25999-20-6 拉沙洛西钠 | CAS号41733-86-2 lasal°Cid benzy... | CAS号73657-53-1 (2S)-2-[(2S,3S,... | CAS号84911-92-2 (3RS,4S)-4-[(2S... | CAS号84911-91-1 (2R)-2-[(2S,3S,... | CAS号31478-26-9 4(R)-[5(S)-ethy... | CAS号73657-51-9 benzyl 2(S)-[5(... | CAS号73657-52-0 benzyl 2(S)-[5(...合成工艺路线路线简述
📜2-(Dibenzylamino)-3-Methyl-6-(3(R)-Methyl-4-Pentenyl)Benzoic Acid Methyl Ester置于palladium On Activated Charcoal 盐酸,Sodium Periodate,四氧化锇,Tetrafluoroboric Acid,正丁基锂,丙烷-1-硫醇,氢气,Potassium Hydride,对甲苯磺酸,N-甲基吗啉氧化物,Zinc(II) Chloride,Lithium Diisopropyl Amide,亚硝酸异戊酯体系中,用 四氢呋喃,甲醇,乙醚,乙醇,水,丙酮,叔丁醇 用作溶剂,50.0 °C,344.73 Kpa 条件下,反应 55.75H,反应生成拉沙洛西
参考文献:The Total Synthesis Of Ionophore Antibiotics. A Convergent Synthesis Of Lasalocid A (X537A)
标题:The Total Synthesis Of Ionophore Antibiotics. A Convergent Synthesis Of Lasalocid A (X537A)
摘要:
Doi:10.1021/ja00345A055
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
1: Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, Witt KL, DeVito M, Freedman JH, Austin CP, Houck KA, Thomas RS, Paules RS, Tice RR, Simeonov A. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environ Health Perspect. 2018 Jul 26;126(7):077010. doi: 10.1289/EHP2589. eCollection 2018 Jul. doi: 10.1016/j.jchromb.2018.04.044. Epub 2018 Apr 30. doi: 10.1080/19440049.2018.1461256. Epub 2018 Jun 6. doi: 10.1002/cmdc.201700631. Epub 2018 Feb 27. doi: 10.1016/j.chemosphere.2018.01.028. Epub 2018 Jan 9. doi: 10.1007/s00436-017-5624-6. Epub 2017 Sep 27.
9: Flythe MD, Kagan IA, Wang Y, Narvaez N. Hops (Humulus lupulus L.) Bitter Acids: Modulation of Rumen Fermentation and Potential As an Alternative Growth Promoter. Front Vet Sci. 2017 Aug 21;4:131. doi: 10.3389/fvets.2017.00131. eCollection 2017. Review.
10: Annunziata L, Visciano P, Stramenga A, Colagrande MN, Campana G, Scortichini G, Migliorati G, Compagnone D. Determination of regulatory ionophore coccidiostat residues in feedstuffs at carry-over levels by liquid chromatography-mass spectrometry. PLoS One. 2017 Aug 9;12(8):e0182831. doi: 10.1371/journal.pone.0182831. eCollection 2017.
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