CAS: 1996-69-6; 1-(4-Methoxyphenoxy)-2-Nitro-4-(Trifluoromethyl)Benzene

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CAS号367-86-2 3-硝基-4-氟三氟甲苯 | CAS号150-76-5 4-甲氧基苯酚(MEHQ)

📜4-氟-3-硝基三氟甲苯,4-甲氧基苯酚置于potassium Fluoride On Basic Alumina,18-冠醚-6体系中,用 乙腈 用作溶剂,化学反应 16.0H,以56%的收率获得4-(4-甲氧基苯氧基)-3-硝基三氟甲苯
参考文献:Synthesis Of Diaryl Ethers,Diaryl Thioethers,And Diarylamines Mediated By Potassium Fluoride−alumina And 18-Crown-6: Expansion Of Scope And Utility1
标题:Synthesis Of Diaryl Ethers,Diaryl Thioethers,And Diarylamines Mediated By Potassium Fluoride−alumina And 18-Crown-6: Expansion Of Scope And Utility1
摘要:An Efficient Alternative To The Ullmann Ether Synthesis Of Diaryl Ethers,Diaryl Thioethers,And Diarylamines Involving The Snar Addition Of A Phenol,Thiophenol,Or Aniline To An Appropriate Aryl Halide,Mediated By Potassium-Fluoride Alumina And 18-Crown-6 In Acetonitrile Or Dmso,Is Described. Expansion Of The Reaction Conditions To Include Dmso As Solvent Has Resulted In A Far Greater Range Of Substitution Patterns Permitted On The Electrophile. For Example,It Was Found That Electronically Unfavorable S-Chlorobenzonitrile Could Be Condensed With 3-Methoxyphenol To Form The Corresponding Diaryl Ether In 66% Yield,A Combination Not Normally Amenable To Ullmann Coupling. Electron-Withdrawing Groups Present On The Electrophile May Be As Diverse As Nitro,Cyano,Formyl,Acetyl,Ester,Amide,And Even Aryl. The Method Features A Simple Reaction Procedure That Provides Products In Generally Good To Excellent Purified Yields.
Doi:10.1021/jo980800G