CAS: 16499-62-0; 4-Chloro-7-Fluoroquinazoline

相似化合物

16499-60-8 791602-75-0 174566-15-5

上下游产品

7-fluoro-3H-quinazolin-4-one methyl 4-fluoroanthranilate 4-fluoroanthranilic acid 7-fluoro-3,4-dihydroquinazolin-4-one -7-fluoroquinazoline4-(3-bromophenyl)amino-7-fluoroquinazoline N-[4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(7-fluoroquinazolin-4-ylamino)benzamide

📜2-氨基-4-氟苯甲酸甲酯置于三氯氧磷体系中,化学反应生成4-氯-7-氟喹唑啉
参考文献:小分子磷酸二酯酶探针:发现有效和选择性的cns穿透性pde1喹唑啉抑制剂†
标题:小分子磷酸二酯酶探针:发现有效和选择性的cns穿透性pde1喹唑啉抑制剂†
摘要:Pde1是在中枢神经系统和周围区域表达的钙激活双底物磷酸二酯酶家族,在细胞内钙和环状核苷酸信号级联反应的整合中发挥作用.由于缺乏有效,选择性和脑穿透性的pde1抑制剂,阻碍了针对这种酶家族治疗神经精神疾病的潜力的探索.为了鉴定此类化合物,我们使用了高通量筛选,基于结构的设计和针对性的合成化学,以发现4-氨基喹唑啉7A(pf-04471141)和4-茚满基喹唑啉27(pf-04822163)每种都是易于穿越血脑屏障的pde1抑制剂.这些基于喹唑啉的pde1选择性抑制剂代表了有价值的新工具,可用于研究pde1调节的生物学过程并开始确定此类化合物治疗神经精神疾病的潜在治疗作用.
Doi:10.1039/c4Md00113C

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:CA-2611219-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:CN-101243065-A
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:KR-20080033234-A
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis