CAS: 1643-15-8; 2-(M-Tolyloxy)Acetic Acid

该化合物是一种多用途有机化合物,其特征是其芬氧乙酸结构,其代用品在元体位置上具有甲基替代成分.该化合物通常用作有机合成的中间体,特别是在生产农用化学品,药品和特殊化学品方面.其活性碳化物和芳香醚混合物组和芳香醚团得以在除草剂配方或精细化学合成等量身定制的应用方面实现功能化.该组增强了脂性,在各种反应条件下影响溶解性和再活动.该组在标准处理条件下具有复合物的稳定性,使之适合工业规模的工艺.其明确界定的结构确保了合成途径的一贯性,支持精确的化学修改.

结构式图片

相似化合物

13605-19-1 5406-14-4 940-64-7

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

M-Tolyloxyacetic Acid Methyl Ester 63051-20-7
(3-甲基苯氧基)乙酸乙酯 Ethyl 3-Methylphenoxyacetate 66047-01-6
(4-甲基苯氧基)乙酸 2-(4-Methylphenoxy)Acetic Acid 940-64-7

合成工艺路线路线简述

  • 90971-89-4 = 1643-15-8 + 90971-89-4
    反应条件:1.1 Solvents: Acetonitrile,Water; Overnight,Ph 9.5,Rt1.2 Reagents: Ethanol1.3 Reagents: Molybdenum Hexacarbonyl,Cesium Hydroxide Catalysts: Palladate(1-),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc]Chloro[2′-(Dicyclohexylphos... Solvents: 1-Methoxy-2-Propanol,Water; 15 H,80 °C
    标题:Palladium-Catalyzed Hydroxycarbonylation Of (Hetero)Aryl Halides For Dna-Encoded Chemical Library Synthesis
    作者:Li,Jian-Yuan; Miklossy,Gabriella; Modukuri,Ram K.; Bohren,Kurt M.; Yu,Zhifeng; Et Al
    参考文献:Bioconjugate Chemistry 日期:2019 卷标:30(8) 页码:2209-2215
📜M-Tolyloxyacetic Acid Methyl Ester置于lithium Hydroxide体系中,用 甲醇,水 用作溶剂,化学反应 12.0H,反应生成3-甲苯氧基乙酸
参考文献:新型除草剂4-羟基-3-(2-苯氧基乙酰基)-吡喃-2-酮衍生物的设计,合成及作用方式评价
标题:新型除草剂4-羟基-3-(2-苯氧基乙酰基)-吡喃-2-酮衍生物的设计,合成及作用方式评价
摘要:为了开发含有β-三酮基序的新型除草剂,设计并合成了一系列4-羟基-3-(2-苯氧基乙酰基)-吡喃-2-酮衍生物.生物测定结果表明,即使剂量为187.5 G Ha-1,化合物ii15也具有非常好的芽前除草活性.此外,与商业除草剂2,4-二氯苯氧基乙酸(2,4-D)相比,化合物ii15的杂草控制范围更广,并且对小麦和玉米具有非常好的农作物安全性.当以375 G Ha-1施用时在出苗前的条件下,表明其作为除草剂的巨大潜力.更重要的是,研究化合物ii15的分子作用方式表明,新的三酮结构是其相应的苯氧乙酸生长素除草剂的除草剂,其除草机理与2,4-D相似.目前的工作表明4-羟基-3-(2-苯氧基乙酰基)-吡喃-2-酮基序可能是潜在的铅结构,用于进一步开发新型的生长素型除草剂.
Doi:10.1021/acs.Jafc.9B03109

海关参考信息

专利信息


专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:US-2002045747-A1
优先权日:1996-12-23
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2002052359-A1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2002173504-A1
优先权日:1996-12-23
标题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2004043977-A1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

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主要参考文献

参考标题:Synthesis And In-Vitro Antimicrobial Activity Of New 1,2,4-Triazoles
作者:A R Bhat,G Varadaraj Bhat,G Gautham Shenoy |发布日期:2010.2.18
摘要:Described The Synthesis Of New 1,2,4-Triazoles And Have Evaluated Their Antimicrobial Profile. Antitubercular Activity Was Determined In Triplicate Using The Lowenstein-Jensen Medium. A Loopful Of Mycobacterium Tuberculosis Suspension Was Inoculated On The Surface Of Each Lowenstein-Jensen Media Containing The Test Compounds (100, 10 Or 1 Microg Ml(-1)). To Evaluate In-Vitro Antibacterial Activity, Compounds

合成参考文献


摘要:Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry., 26(1204), 1987
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