CAS: 14172-55-5; 1-(Phenylsulfonyl)Piperazine

相似化合物

27106-51-0 17046-84-3 412293-98-2

上下游产品

1-Benzolsulfonyl-4-ethoxycarbonyl-piperazin piperazinium N-fluorobis(benzenesulfon)imide tert-butyl 4-(phenylsulfonyl)piperazine-1-carboxylate 4-methylpiperazin-1-ylbenzenesulfonamide 4-benzenesulfonyl-piperazine-1-carbonyl chloride 4-methanesulfonylpiperazine

📜1-(4-氯苯磺酰基)-哌嗪置于2-双环己基膦-2',6'-二甲氧基联苯,三乙基硅烷,三乙胺,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 1,4-二氧六环 用作溶剂,化学反应 16.0H,以77%的收率获得1-苯磺酰基哌嗪
参考文献:Expanding The Scope Of Silane-Mediated Hydrodehalogenation Reactions
标题:Expanding The Scope Of Silane-Mediated Hydrodehalogenation Reactions
摘要:A Palladium-Catalysed,Silane-Mediated Hydrodehalogenation (Hdh) Reaction With Increased Substrate Scope Has Been Developed. Whereas Previous Attempts To Reduce Carboxylic Acid Or Phenol-Containing Aryl Halides Using Silane-Based Hdh Conditions Failed,The Current Protocol Allows Efficient Access To The Reduced Products. Chemoselective Hdh In The Presence Of Sensitive Functional Groups Is Also Presented. (C) 2013 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2013.06.063

专利信息

专利号:US-10675366-B2
优先权日:2016-08-12
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：BEINAT CORRINE GAYE; ALAM ISRAT SHAMIMA; JAMES MICHELLE L; GAMBHIR SANJIV S; SRINIVASAN ANANTH
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

专利号:US-2003199693-A1
优先权日:2000-07-28
标题 :Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase
发明人：CHEN ING-JUN
摘要:Compounds of the theophylline and 3-isobutyl-1-methylxanthine (IBMX) based on N-7 substituted derivatives, X being florine, chlorine, bromine or iodine, are provided. These compounds possess pharmacologically inhibitory activities on PDE-5 Phosphodiesterase, relaxation of corpus carvernosal smooth muscle and increase of intracarvernosal pressure (ΔICP). A process is also provided for the synthesis of some novel theophyline derivatives.

专利号:US-2005059817-A1
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-0-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

专利号:CN-101535336-A
优先权日:2006-11-10
标题 :Synthesis of Phthalamide and Its Dimer

专利号:US-6686463-B2
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.