CAS: 133627-45-9; 2-Chloro-4-Methylpyridin-3-Amine

相似化合物

23056-39-5 129432-25-3 66909-38-4

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CAS号152362-01-1 2-氯-4-甲基烟酰胺 | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号23056-39-5 2-氯-4-甲基-3-硝基吡啶 | CAS号5832-44-0 4-甲基-3-硝基吡啶 | CAS号50839-95-7 2-Chloro-4-meth... | CAS号50840-02-3 2-氯-4-甲基-烟酸乙酯 | CAS号142266-63-5 2-氯-4-甲基烟酸 | CAS号152362-00-0 ethyl 2-chloro-... | CAS号93271-59-1 2-羟基-4-甲基吡啶-3-甲腈 | CAS号65169-38-2 2-氯-3-氰基-4-甲基吡啶 | CAS号1060812-96-5 3-bromo-2-ethox... | CAS号55404-31-4 2-氯-3-溴-4-甲基吡啶 | CAS号76006-11-6 7-氯-1H-吡唑并[3,4-c]吡啶 | CAS号717843-51-1 3-溴-2-甲氧基-4-甲基吡啶 | CAS号133627-47-1 N-(2-氯-4-甲基-3-吡... | CAS号133627-18-6 11-ethyl-4,5-di... | CAS号133627-17-5 奈韦拉平相关物质A | CAS号1038920-08-9 6-溴-2-氯-4-甲基吡啶-3-胺 | CAS号133627-46-0 2-氯-N-(2-氯-4-甲基... | CAS号129618-40-2 奈韦拉平

α-甲基-γ-丁内酯置于盐酸,双氧水,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二氯甲烷,氯仿,水 用作溶剂,20.0~45.0 °C,300.01 Kpa 条件下,反应 21.0H,反应生成2-氯-3-氨基-4-甲基吡啶
参考文献:一种4-甲基哌啶-3-酮及其衍生物的简便制备 方法
标题:一种4-甲基哌啶-3-酮及其衍生物的简便制备 方法
摘要:本发明涉及一种4‑甲基哌啶‑3‑酮及其衍生物的简便制备方法.本发明利用α‑甲基‑γ‑丁内酯和硝基甲烷反应制备1‑硝基‑3‑甲基‑5‑羟基正戊‑2‑酮,然后经磺酰氯试剂保护羟基得到1‑硝基‑3‑甲基‑5‑保护氧基正戊‑2‑酮,再经加氢还原硝基为氨基,同时环化得到4‑甲基哌啶‑3‑酮.本发明还提供由4‑甲基哌啶‑3‑酮制备2‑氯‑3‑氨基‑4‑甲基吡啶,N‑苄基‑4‑甲基哌啶‑3‑酮的方法.本发明所用原料价廉易得,条件温和,操作简便安全,反应选择性高,产品收率和纯度高,成本低,三废量少,绿色环保.

专利信息

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:WO-2016118586-A1
优先权日:2015-01-20
标 题 :Lowcost, high yield synthesis of nevirapine
发明人：AHMAD SAEED; GUPTON FRANK; VERGHESES JENSON; MCQUADE TYLER
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Improved methods of producing the HIV drug substance, nevirapine are provided. The methods employ a cost effective and high yield synthetic methods for preparing the nevirapine building block 2-chloro-3-amino-4-picoline (CAPIC) and 2-cyclopropyl amino nicotinate (Me-CAN), and improvements in other steps of nevirapine synthesis.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:US-6111112-A
优先权日:1999-01-22
标题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
发明人：GROZINGER KARL
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme. ##STR1##

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound

专利号:US-6136982-A
优先权日:1999-01-22
标 题:Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate
发明人：GROZINGER KARL
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme. ##STR1##