CAS: 13036-02-7; Dimethyl 5-Hydroxyisophthalate

该化合物是属于异眼类的有机化合物,其特征是两个甲氧基组(-OCH3)和一个附于苯环的氢氧基组(-OH),具体而言,与碳箱状组相比,其位置为5;该化合物一般为白色至白外晶状固体,在甲醇和乙醇等有机溶剂中溶解,但在水中溶解性有限;二甲基5-羟基异丙酸盐主要用于聚酯和其他聚合材料的合成,有助于高性能塑料的开发;其氢氧基组可参与氢的结合,增强其在各种化学过程中的再活性;此外,多种功能组的存在允许进一步衍生,使其在有机合成中成为多功能中间体;应参考安全数据处理和接触准则,如任何化学物质.

结构式图片

相似化合物

618-83-7 144876-14-2 69026-10-4

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

methanol 5-Hydroxyisophthalic acid 3,5-bis(methoxycarbonyl)phenyl trifluoromethanesulfonate 5-Hydroxybenzene-1,3-dicarbonyl dichloride5-carboxymethoxy-isophthalic acid dimethyl ester dimethyl 5-(heptyloxy)isophthalate 5-decyloxyisophthalic acid 1,3,5-tris-[3,5-bis(methoxycarbonyl)phenoxymethyl]benzene

合成工艺路线路线简述

  • 合成目标产物 Dimethyl 5-Hydroxyisophthalate 主要起始原料 5-Hydroxyisophthalic Acid
  • (文献来源)合成步骤主要原料 5-Hydroxyisophthalic Acid
📜5-羟基间苯二甲酸置于三氟化硼乙醚体系中,用 甲醇 用作溶剂,以78%的收率获得5-羟基间苯二甲酸二甲酯
参考文献:接头功能化触发了间苯二甲酸锌4,4'-联吡啶骨架的3D拓扑结构
标题:接头功能化触发了间苯二甲酸锌4,4'-联吡啶骨架的3D拓扑结构
摘要:制备并表征了一系列四个含有官能化间苯二甲酸酯连接基和4,4'-联吡啶柱的zn 2+金属有机骨架.包含-oc 3 H 2 N +1烷氧基侧链(n = 1,2或3)的间苯二甲酸酯形成具有3D柱状层拓扑结构的框架,而不是具有指状结构的著名配位聚合物的典型2D层拓扑结构( Cids),用于较短的-oc 2 H 5侧链.在低温下使用n 2,Co 2和o 2吸附测量来分析材料的气体吸附性能.
Doi:10.1039/c7Dt01195D

海关参考信息

专利信息


专利号:US-6962963-B2
优先权日:2002-10-18
标题 :Enzymatic synthesis of polymers
发明人:KUMAR RAJESH; WATTERSON ARTHUR C; PARMAR VIRINDER SINGH; KUMAR JAYANT; SAMUELSON LYNNE ANN
权利人:UNIV MASSACHUSETTS
摘要:The invention relates to new methods of enzymatic synthesis of polymers such as polyorganosilicones and polyesters, and new polymers made by these methods.

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人:KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:US-8722846-B2
优先权日:2011-12-08
标题 :Preparation of homopolymer and copolymers of (phosphonyl)aromatic diesters and acids
发明人:DRYSDALE NEVILLE EVERTON; NEDERBERG FREDRIK
权利人:DRYSDALE NEVILLE EVERTON; NEDERBERG FREDRIK; DU PONT
摘要:The composition of a homopolymer of (phosphonyl) aromatic diester compound using a catalyst and a glycol is provided. Further, the composition of a copolymer of the (phosphonyl) aromatic diester compound using a catalyst, a glycol and a second diester is provided. These polymers find application as flame retardants during synthesis of various polymeric materials.

专利号:US-9193659-B2
优先权日:2008-02-20
标 题 :Process for the iodination of aromatic compounds
发明人:GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO
权利人:GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-8779186-B2
优先权日:2009-09-02
标题 :Process for the synthesis of fluorinated ethers of aromatic acids
发明人:DRYSDALE NEVILLE EVERTON; MOLOY KENNETH GENE; RITTER JOACHIM C; POLLINO JOEL M; MAHAJAN DU SURBHI
权利人:DRYSDALE NEVILLE EVERTON; MOLOY KENNETH GENE; RITTER JOACHIM C; POLLINO JOEL M; MAHAJAN DU SURBHI; DU PONT
摘要:New fluorinated ethers of aromatic acids and diesters are disclosed. These compositions can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.

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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Denis Nilov, Et Al. Synthesis Of 5-Substituted Derivatives Of Isophthalic Acid As Non-Polymeric Amphiphilic Coating For Metal Oxide Nanoparticles. Tetrahedron Lett. 2014 Sep 3;55(36):5078-5081.
[参考文献]: J F Nierengarten, Et Al. Amphiphilic Diblock Dendrimers: Synthesis And Incorporation In Langmuir And Langmuir-Blodgett Films. J Am Chem Soc. 2001 Oct 10;123(40):9743-8.
[参考文献]: Jeny Karabline, Et Al. Solid-Phase Synthesis And Acidolytic Degradation Of Sterically Congested Oligoether Dendrons. Org Biomol Chem. 2012 Jun 28;10(24):4788-94.
[参考文献]: Rajesh Kumar, Et Al. Enzymatic Synthesis Of Multi-Component Copolymers And Their Structural Characterization. Mol Divers. 2003;6(3-4):287-95.

合成参考文献


参考文献:10.1155/2011/902403
摘要:Panagiotou T, Fisher RJ. Enhanced Transport Capabilities via Nanotechnologies: Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones. Journal of Drug Delivery. 2011 Apr 26;2011():1–14. doi: 10.1155/2011/902403.
参考文献:10.1038/nchem.1506
摘要:Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem. 2013 Jan;5(1):21–8. doi: 10.1038/nchem.1506.
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