专利号:US-9938312-B2 优先权日:2011-03-25 标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans 发明人:BOONS GEERT-JAN; WANG ZHEN 权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA 摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
专利号:US-2023406804-A1 优先权日:2018-10-12 标题:Protein kinase inhibitors 发明人:SRIDHAR JAYALAKSHMI; JONES FRANK; STEVENS CHERYL 权利人:XAVIER UNIV OF LOUISIANA; THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND 摘要:The present disclosure relates to compounds that act as protein kinase inhibitors, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer.
专利号:US-6235871-B1 优先权日:1997-12-03 标题:Synthesis of oligoarylamines, and uses and reagents related thereto 发明人:SINGER ROBERT A; SADIGHI JOSEPH P; BUCHWALD STEPHEN L; MACKEWITZ THOMAS 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common organic solvents, and are easily converted to the deprotected oligoanilines. The method allows the preparation of oligoanilines of even or odd chain lengths, and the incorporation of a variety of functional groups into the oligomers. Polyanilines of low polydispersity can also be prepared by this method.
专利号:US-12168649-B2 优先权日:2018-08-17 标 题 :Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives 发明人:WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL 权利人:BASF SE 摘要:The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.
专利号:US-9670240-B2 优先权日:2014-05-02 标题 :Cyclic phosphinate derivatives and method of preparing the same 发明人:LEE PHIL HO; SHIN SEO HYUN; KANG DONG JIN; EOM DA HAN; KIM YEA RIN; JEONG YEON SEOK; CHOI WON SEOK 权利人:KNU INDUSTRY COOPERATION FOUND 摘要:Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including benzoxaphosphole oxide derivatives and benzoxaphosphorin oxide derivatives, and a method of preparing the same. The cyclic phosphinate derivative according to the present invention may have pharmacological and physiological activities, be used as the basic skeleton of the natural material, and be used in development of a new drug, and synthesis of various medicines. In addition, with the method of preparing a cyclic phosphinate derivative according to the present invention, various cyclic phosphinate derivatives may be prepared with high yield through a simple synthetic process by performing an intramolecular carbon-oxygen coupling reaction on the phosphinic acid derivative in the presence of a palladium (Pd) catalyst, an oxidant, and a base.
专利号:US-9493494-B2 优先权日:2014-05-30 标题:Phosphinine oxide derivative and preparation method thereof 发明人:LEE PHIL HO; PARK YOUNG CHUL; JEON IN CHEOL; SEO JUNG MIN; SEO BO RAM 权利人:KNU INDUSTRY COOPERATION FOUND 摘要:Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative. n The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies. n In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.
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