CAS: 126-18-1; (2Ar,4S,5'R,6As,6Bs,8As,8Br,9S,10R,11As,12As,12Br)-5',6A,8A,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-Ol

上下游产品

(25R)-5β-spirostan-3-one (25R)-spirost-4-ene-3-one diosgenin sarsasapogenin(25R)-5β-spirostan-3α-ol acetate O-(toluene-4-sulfonyl)-epismilageninO-(toluene-4-sulfonyl)-epismilagenin smilagenin acetate O-Benzoyl-smilageninO-Benzoyl-smilagenin

📜(25R)-螺甾-4-烯-3-酮置于sodium Tetrahydroborate,5%-Palladium/activated Carbon,氢气体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 4.0H,反应生成菝葜
参考文献:薯蓣皂苷元衍生物,其药物组合物及其应用
标题:薯蓣皂苷元衍生物,其药物组合物及其应用
摘要:本发明涉及一种薯蓣皂苷元衍生物,所述的薯蓣皂苷元衍生物的结构式如通式(1)所示,本发明还提供了上述薯蓣皂苷元衍生物的药物组合物及其应用,首次对该先导化合物进行了系统性的针对3位和5/6位双键进行结构修饰,合成了一系列新化合物,这些新化合物通过相关靶点的活性测试,很多显示出优于先导化合物的活性,对于治疗神经退行性疾病十分有价值.弥补了现有技术中薯蓣皂苷元衍生物的不足,十分有意义.

专利信息

专利号:EP-1172094-B1
优先权日:2000-07-13
标题:Composition, particularly for cosmetics, comprising DHEA and/or precursor or derivative, and at least a compound which increases the synthesis of glycosaminoglycans
发明人：ALLEC JOSIANE; CLEREN NATHALIE
权利人:OREAL
摘要:Cosmetic composition comprises: (a) dehydroepiandrosterone (DHEA) and/or a DHEA precursor or derivative; and (b) a compound that promotes glycosaminoglycan synthesis or a natural extract containing such a compound.

专利号:UA-81133-C2
优先权日:2002-10-28
标 题 :Process of stereospecific synthesis of 3-hydroxy-5?-h steroidal sapogenins, process of conversion and processes for the preparation of smilagenin and epismilagenin

专利号:EP-3002290-B1
优先权日:2007-06-19
标 题:Synthesis of deoxycholic acid (dca)
发明人：MORIARTY ROBERT M; DAVID NATHANIEL E; MAHMOOD NADIR AHMEDUDDIN; PRASAD ACHAMPETA RATHAN; SWARINGEN ROY A JR; REID JOHN GREGORY; SAHOO AKHILA KUMAR
权利人:ALLERGAN SALES LLC

专利号:US-11427476-B2
优先权日:2016-04-22
标题:Mesoporous silicas and method for the synthesis thereof
发明人：CROIZET-BERGER Karine; DELMEULE Maxime; ESTAGER JULIEN; MANNU NICOLAS; KARTHEUSER BENOIT
权利人:SILINNOV S C R L
摘要:The present invention provides a mesoporous silica comprising of components A and B such that component A is a surfactant of a saponin family and component B is a precursor of a silica. The present inventions also provides a method of producing said mesoporous silica by mixing components A and B in a solvent.

专利号:EP-3002290-A2
优先权日:2007-06-19
标 题 :Synthesis of deoxycholic acid (dca)

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.