CAS: 95091-92-2; N-Methoxy-N-Methylfuran-2-Carboxamide

该化合物是一种化学化合物,其独特结构包括一个呋喃环,一个甲氧基组和一个碳本甲胺功能组,该化合物通常具有与氨化物和乙醚有关的特性,例如有机溶剂中中度极度和潜在溶解性.呋喃环的存在有助于其芳香特性,可能影响其再活性和稳定性.N-methoxy-N-甲基furan-2-carboxamide可能参与各种化学反应,包括核生殖器替代和凝聚反应,因为存在功能组.此外,该化合物的分子结构表明,在药物或农用化学物中具有潜在用途,这种化合物可以作为中间或活性成分.应当与任何化学物质一道,观测安全和处理预防措施,以减轻与接触或再活性有关的风险.

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CAS号527-69-5 糠酰氯 | CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号88-14-2 糠酸; 2-糠酸; 2-呋喃甲酸 | CAS号611-13-2 2-糠酸甲酯 | CAS号1062512-43-9 N,N',N''-phosph... | CAS号1117-97-1 甲氧基甲基胺 | CAS号14360-50-0 正戊基-2-呋喃酮 | CAS号21402-85-7 N-methylfuran-2... | CAS号2975-99-7 1-(furan-2-yl)-... | CAS号90086-89-8 2-(呋喃-2-基)吡咯烷 | CAS号15817-51-3 (4-fluorophenyl... | CAS号6790-18-7 1-(furan-2-yl)d...

合成工艺路线路线简述

  • 合成目标产物 N-Methoxy-N-Methyl-2-Furamide 主要起始原料 2-Furoyl Chloride And N,O-Dimethylhydroxylamine Hydrochloride
  • 6638-79-5 + 611-13-2 = 95091-92-2
    反应条件:1.1 Catalysts: Chlorodimethylaluminum Solvents: Dichloromethane
    标题:Efficient Method For Preparation Of N-Methoxy-N-Methyl Amides By Reaction Of Lactones Or Esters With Me2Alcl-Meonhme.HCL
    作者:Shimizu,Takeshi; Osako,Katsuhisa; Nakata,Tadashi
    参考文献:Tetrahedron Letters 日期:1997 卷标:38(15) 页码:2685-2688]

    1117-97-1 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Oxalyl Chloride,Diphenylcyclopropenone Solvents: Dichloromethane1.2 Reagents: Diisopropylethylamine; Rt1.3 Solvents: Dichloromethane; Rt
    标题:One-Pot Synthesis Of Weinreb Amides Employing 3,3-Dichloro-1,2-Diphenylcyclopropene (Cpi-Cl) As A Chlorinating Agent
    作者:M,Shekharappa; Kumar L,Roopesh; Sureshbabu,Vommina V.
    参考文献:Synthetic Communications 日期:2019 卷标:49(6) 页码:790-798]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane; 1 H,Rt1.2 Reagents: Triethylamine; Overnight,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 10 Min,Rt
    标题:A Co2-Catalyzed Transamidation Reaction
    作者:Yang,Yang; Liu,Jian; Kamounah,Fadhil S.; Ciancaleoni,Gianluca; Lee,Ji-Woong
    参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(23) 页码:16867-16881]

    1117-97-1 = 95091-92-2
    反应条件:1.1 Reagents: Diisopropylethylamine,Poly(Oxy-1,2-Ethanediyl),α-[4-[[3,4-Dihydro-2,5,7,8-Tetramethyl-2-(4,8,12-Trime... Solvents: Water; 0.5 - 3 H,0 °C
    标题:Simple Synthesis Of Amides Via Their Acid Chlorides In Aqueous Tpgs-750-M
    作者:Shi,Min; Ye,Ning; Chen,Wei; Wang,Hui; Cheung,Chiming; Et Al
    参考文献:Organic Process Research & Development 日期:2020 卷标:24(8) 页码:1543-1548]

    6638-79-5 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; 1 H,Rt
    标题:A Biosynthesis-Inspired Approach To Over Twenty Diverse Natural Product-Like Scaffolds
    作者:Firth,James D.; Craven,Philip G. E.; Lilburn,Matthew; Pahl,Axel; Marsden,Stephen P.; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2016 卷标:52(63) 页码:9837-9840]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Trichloroacetamide,Triphenylphosphine Solvents: Dichloromethane; Rt; 1 H,Rt1.2 Reagents: Triethylamine; Rt; 1 H,Rt
    标题:A Convenient One-Pot Method For The Synthesis Of N-Methoxy-N-Methyl Amides From Carboxylic Acids
    作者:Kim,Joong-Gon; Jang,Doo Ok
    参考文献:Bulletin Of The Korean Chemical Society 日期:2010 卷标:31(1) 页码:171-173]

    6638-79-5 + 611-13-2 = 95091-92-2
    反应条件:1.1 Solvents: Tetrahydrofuran; 5 Min,-20 °C1.2 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Diethyl Ether; 15 Min,-20 °C; 10 Min,-20 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; -20 °C -> 18 °C; 10 Min,18 °C
    标题:Synthesis Of Functionalised 4H-Quinolizin-4-Ones Via Tandem Horner-Wadsworth-Emmons Olefination/cyclisation
    作者:Muir,Calum W.; Kennedy,Alan R.; Redmond,Joanna M.; Watson,Allan J. B.
    参考文献:Organic & Biomolecular Chemistry 日期:2013 卷标:11(20) 页码:3337-3340]

    30289-28-2 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Acetonitrile
    标题:An Efficient Synthesis Of N-Methoxy-N-Methylamides From Carboxylic Acids Using N-Methoxy-N-Methylcarbamoyl Chloride
    作者:Lee,Jae In; Park,Hyun
    参考文献:Bulletin Of The Korean Chemical Society 日期:2002 卷标:23(3) 页码:521-524]

    1117-97-1 + 88-14-2 = 95091-92-2
    反应条件:1.1 Solvents: Toluene; 10 Min,0 °C1.2 Reagents: Phosphorus Trichloride Solvents: Toluene; 0 °C; 0 °C -> Rt; 0.5 H,60 °C; 60 °C -> Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:One-Pot Transition-Metal-Free Synthesis Of Weinreb Amides Directly From Carboxylic Acids
    作者:Niu,Teng; Wang,Ke-Hu; Huang,Danfeng; Xu,Changming; Su,Yingpeng; Et Al
    参考文献:Synthesis 日期:2014 卷标:46(3) 页码:320-330]

    1062512-43-9 + 88-14-2 = 95091-92-2
    反应条件:1.1 Solvents: Toluene; 0.5 - 1 H,60 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:A Powerful Reagent For Synthesis Of Weinreb Amides Directly From Carboxylic Acids
    作者:Niu,Teng; Zhang,Weiming; Huang,Danfeng; Xu,Changming; Wang,Haifeng; Et Al
    参考文献:Organic Letters 日期:2009 卷标:11(19) 页码:4474-4477]

    1117-97-1 = 95091-92-2
    反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane
    标题:Stereoselective Synthesis Of Substituted N-Heterocycles Via Sequential Cross Metathesis-Reductive Cyclization
    作者:Gebauer,Julian; Dewi,Purnama; Blechert,Siegfried
    参考文献:Tetrahedron Letters 日期:2005 卷标:46(1) 页码:43-46]

    1117-97-1 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Oxalyl Chloride Solvents: Dimethylformamide,Dichloromethane; 1.5 H,Rt1.2 Reagents: Triethylamine Solvents: Dichloromethane; 2 H,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:Versatile Synthesis Of Acylfuranones By Reaction Of Acylketenes With α-Hydroxy Ketones: Application To The One-Step Multicomponent Synthesis Of Cadiolide B And Its Analogues
    作者:Peixoto,Philippe Alexandre; Boulange,Agathe; Leleu,Stephane; Franck,Xavier
    参考文献:European Journal Of Organic Chemistry 日期:2013 卷标:2013(16) 页码:3316-3327]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 2 H,Rt1.2 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; Overnight,Rt
    标题:Palladium-Catalyzed Borylative Cyclizations Of α-(2-Bromoaryl) Ketones To Form 1,2-Benzoxaborinines
    作者:Shigeno,Masanori; Iseya,Yuto; Kume,Ryotaro; Nozawa-Kumada,Kanako; Kondo,Yoshinori
    参考文献:Organic Letters 日期:2022 卷标:24(39) 页码:7227-7231]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine,S,S-Di-2-Pyridinyl Carbonodithioate Solvents: Acetonitrile1.2 Reagents: Triethylamine1.3 Solvents: Tetrahydrofuran1.4 Solvents: Hexane,Ethyl Acetate
    标题:A Convenient Synthesis Of N-Methoxy-N-Methylamides From Carboxylic Acids Using S,S-Di-2-Pyridyl Dithiocarbonate
    作者:Lee,Jae In; Park,Hyun
    参考文献:Bulletin Of The Korean Chemical Society 日期:2001 卷标:22(4) 页码:421-423]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine,Propylphosphonic Anhydride Solvents: Tetrahydrofuran,Ethyl Acetate; 10 Min,0 - 5 °C1.2 0 - 5 °C; 80 Min,25 °C
    标题:A New Strategy For Accessing (S)-1-(Furan-2-Yl)Pent-4-En-1-Ol: A Key Precursor Of Ipomoeassin Family Of Compounds And C1-C15 Domain Of Halichondrins
    作者:Jammula,Subba Rao; Anna,Venkateswara Rao; Tatina,Sudhakar; Krishna,Thalishetti; Sreenivas,B. Yogi; Et Al
    参考文献:Tetrahedron Letters 日期:2016 卷标:57(35) 页码:3924-3928]

    6638-79-5 = 95091-92-2
    反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: 2-Methyltetrahydrofuran,Water; 2 Min,0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized,Rt
    标题:Highly Efficient And Environmentally Benign Preparation Of Weinreb Amides In The Biphasic System 2-Methf/water
    作者:Pace,Vittorio; Castoldi,Laura; Alcantara,Andres R.; Holzer,Wolfgang
    参考文献:Rsc Advances 日期:2013 卷标:3(26) 页码:10158-10162]

    6638-79-5 = 95091-92-2
    反应条件:1.1 Solvents: Chloroform; Rt -> 0 °C1.2 Reagents: Pyridine; 0 °C; 15 Min,0 °C; Overnight,0 °C -> Rt
    标题:Method Of Making 2-Furyl Alkyl Ketones
    参考文献:United States]

    1117-97-1 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 10 Min,0 °C; Overnight,Rt
    标题:Direct Alkoxycarbonylation Of Heteroarenes Via Cu-Mediated Trichloromethylation And In Situ Alcoholysis
    作者:Luo,Wenkun; Jiang,Kai; Li,Yingwei; Jiang,Huanfeng; Yin,Biaolin
    参考文献:Organic Letters 日期:2020 卷标:22(5) 页码:2093-2098]

    6638-79-5 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 12 H,0 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Palladium-Catalyzed Hydrocarbonylative Cyclization Of 1,5-Dienes
    作者:Zou,Suchen; Gao,Bao; Huang,Yao; Zhang,Tianze; Huang,Hanmin
    参考文献:Organic Letters 日期:2019 卷标:21(16) 页码:6333-6336]

    6638-79-5 + 88-14-2 = 95091-92-2
    反应条件:1.1 Reagents: Triethylamine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 15 Min,0 °C; 0 °C -> 22 °C; 6 H,22 °C1.2 Reagents: Citric Acid Solvents: Water; 22 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; Ph 7 - 8,22 °C
    标题:Aluminum-Catalyzed Asymmetric Alkylations Of Pyridyl-Substituted Alkynyl Ketones With Dialkylzinc Reagents
    作者:Friel,Donna K.; Snapper,Marc L.; Hoveyda,Amir H.
    参考文献:Journal Of The American Chemical Society 日期:2008 卷标:130(30) 页码:9942-9951
📜糠酸(呋喃甲酸)置于草酰氯,三乙胺,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.5H,反应生成 N-甲氧基-N-甲基-2-呋喃甲酰胺
参考文献:酰基乙烯酮与 α-羟基酮反应合成酰基呋喃酮:在一步多组分合成 Cadiolide B 及其类似物中的应用
标题:酰基乙烯酮与 α-羟基酮反应合成酰基呋喃酮:在一步多组分合成 Cadiolide B 及其类似物中的应用
摘要:在碱性条件下,在羟基酮的存在下,通过相应的二恶英酮的热裂解,以一步法制备了官能化的酰基呋喃酮.添加醛作为第三个反应伙伴时也会发生多组分反应,从而快速获得卡地内酯 B 及其类似物.
DOI:10.1002/ejoc.201300166

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合成参考文献


参考文献:10.1055/s-2008-1078240
摘要:Murphy J, Cutulic S, Farwaha H, Zhou S, Chrystal E. Metal-Free Reductive Cleavage of N-O Bonds in Weinreb Amides by an Organic Neutral Super-Electron Donor. Synlett. 2008 Aug;2008(14):2132–6. doi: 10.1055/s-2008-1078240.
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