CAS: 91296-87-6; 6-Fluoro-1-(4-Fluorophenyl)-4-Oxo-7-(Piperazin-1-yl)-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride

C24H22Bf2N3O7置于盐酸体系中,用 水 作为反应溶剂,化学反应 4.0H,以95.4%的收率获得产物盐酸沙拉沙星
参考文献:喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法
标题:喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法
摘要:本发明属于医药化工领域,涉及喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法,具体涉及7‑取代‑3‑喹诺酮羧酸衍生物或7‑取代‑1,5‑二氮杂萘酮羧酸衍生物的制备方法.所述的制备方法包括如下步骤:(1)在有机溶剂中,将硼螯合物ii与有机胺iii在有机硅化合物下发生偶联反应,得到化合物iv;(2)将化合物iv与盐酸混合,随后过滤分离沉淀的化合物i.本发明所述制备方法相比于传统方法,它条件更为温和,能够减少底物喹啉羧酸硼酸酯的水解,同时避免了副产物hf对产品纯度的影响,收率高,纯度高,使用有机硅相比于传统的碱,更适合用于7‑取代‑3‑喹诺酮羧酸衍生物或7‑取代‑1,5‑二氮杂萘酮羧酸衍生物的工业制备.

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:WO-2023168108-A2
优先权日:2022-03-04
标 题 :Synthesis of sulfur(vi) compounds and reagents for same

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:CN-101208345-B
优先权日:2005-05-25
标 题 :(S) -N-methylnaltrexone, method of synthesis and pharmaceutical use thereof