CAS: 874-61-3; 4-Oxocyclohexanecarboxylic Acid

该化合物是有机化合物,其特点是环环结构,其特征为盒状酸组和一个可功能组,该化合物一般是白色的,非白色的固体,由于存在箱状酸类,在极地溶剂中可溶解,其分子结构包括六人碳环,其中碳基组(C=O)和碳酸组(EuroCOOH)位于特定位置,有助于其再活性和有机合成中的潜在应用,这些功能组的存在允许各种化学反应,包括酯化和凝聚反应.此外,四氧环形碳酸可能展示生物活动,使其对制药研究感兴趣,其稳定性和再活性可能受到温度和pH等环境因素的影响,而温度和PH是化学工艺中处理和应用的重要考虑因素.

结构式图片

相似化合物

17159-79-4 6297-22-9 96184-81-5

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

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合成工艺路线路线简述

  • 57899-62-4 = 874-61-3
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 24 H,Reflux
    标题:Oligo(Cyclohexylidene)S And Oligo(Cyclohexyl)S As Bridges For Photoinduced Intramolecular Charge Separation And Recombination
    作者:Oosterbaan,Wibren D.; Et Al
    参考文献:Journal Of Physical Chemistry A 日期:2003 卷标:107(19) 页码:3612-3624]

    17419-81-7 = 874-61-3
    反应条件:1.1 Reagents: Sulfuric Acid,Ammonium Persulfate Solvents: Water; 3 H,Acidified,70 °C
    标题:The Green Catalytic Oxidation Of Alcohols In Water By Using Highly Efficient Manganosilicate Molecular Sieves
    作者:Manyar,Haresh G.; Et Al
    参考文献:Green Chemistry 日期:2006 卷标:8(4) 页码:344-348]

    98-89-5 = 874-61-3 [标题:Reaction Conditions
    标题:Enzymic Aromatization Of 4-Ketocyclohexanecarboxylic Acid To P-Hydroxybenzoic Acid
    作者:Kaneda,Toshi
    参考文献:Biochemical And Biophysical Research Communications 日期:1974 卷标:58(1) 页码:140-4]

    17159-79-4 = 874-61-3
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Structure-Activity Relationships Of Cycloalkylamide Derivatives As Inhibitors Of The Soluble Epoxide Hydrolase
    作者:Kim,In-Hae; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2011 卷标:54(6) 页码:1752-1761]

    3685-26-5 = 874-61-3
    反应条件:1.1 Reagents: 4-Benzoylpyridine Solvents: Acetone; 48 H,Rt
    标题:Photoinduced Oxidation Of Secondary Alcohols Using 4-Benzoylpyridine As An Oxidant
    作者:Kamijo,Shin; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(13) 页码:3326-3329]

    17159-80-7 = 874-61-3
    反应条件:1.1 Reagents: Alumina,Pyridinium Chlorochromate Solvents: Chloroform2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water2.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Design And Synthesis Of Non-Peptidic Inhibitors For The Syk C-Terminal Sh2 Domain Based On Structure-Based In-Silico Screening
    作者:Niimi,Tatsuya; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2001 卷标:44(26) 页码:4737-4740]

    17159-80-7 = 874-61-3
    反应条件:1.1 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane; 5 °C; 2 H,Rt; 5 H,45 °C2.1 Reagents: Sulfuric Acid; 4 H,Rt -> 115 °C
    标题:Hydrophilic Aliphatic Polyesters: Design,Synthesis,And Ring-Opening Polymerization Of Functional Cyclic Esters
    作者:Trollss,Mikael; Et Al
    参考文献:Macromolecules 日期:2000 卷标:33(13) 页码:4619-4627]

    17419-81-7 = 874-61-3 [标题:Reaction Conditions
    标题:Microbial Degradation Of Cyclohexanecarboxylic Acid. Pathway Involving Aromatization To Form P-Hydroxybenzoic Acid
    作者:Blakley,E. R.
    参考文献:Canadian Journal Of Microbiology 日期:1974 卷标:20(10) 页码:1297-306]

    58660-59-6 = 874-61-3 [标题:Reaction Conditions
    标题:Central Nervous System Active Compounds. Ii. The Synthesis Of Some 4-,5-,6- And 7-Substituted Caprolactams
    作者:Duong,Thach; Et Al
    参考文献:Australian Journal Of Chemistry 日期:1976 卷标:29(12) 页码:2667-82]

    99-96-7 = 874-61-3 [标题:Reaction Conditions
    标题:Process For The Preparation Of 4'-Hydroxybiphenyl-4-Carboxylic Acid,An Intermediate For Polymers And Liquid Crystals
    参考文献:European Patent Organization]

    99-96-7 = 874-61-3 [标题:Reaction Conditions
    标题:4,4-Bis(4-Hydroxyphenyl)Cyclohexanecarboxylic Acid Derivatives And Process For Preparing The Same
    参考文献:European Patent Organization]

    6297-36-5 = 874-61-3
    反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Diethyl Ether; 3 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; 20 °C2.1 Reagents: Hydrochloric Acid Solvents: Water; 24 H,Reflux
    标题:Oligo(Cyclohexylidene)S And Oligo(Cyclohexyl)S As Bridges For Photoinduced Intramolecular Charge Separation And Recombination
    作者:Oosterbaan,Wibren D.; Et Al
    参考文献:Journal Of Physical Chemistry A 日期:2003 卷标:107(19) 页码:3612-3624
📜4-氧代环己烷甲腈置于盐酸体系中,化学反应生成 4-羰基环己羧酸
参考文献:Petrow; Wladimirowa,Zhurnal Obshchei Khimii,1947,Vol. 17,P. 1543,1546
标题:Petrow; Wladimirowa,Zhurnal Obshchei Khimii,1947,Vol. 17,P. 1543,1546

海关参考信息

专利信息


专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:EP-0827496-A1
优先权日:1995-03-07
标题 :Catalic enantioselective synthesis of a spiro-fused azetidinone

专利号:WO-9627587-A1
优先权日:1995-03-07
标题 :Catalic enantioselective synthesis of a spiro-fused azetidinone

专利号:CA-2214580-A1
优先权日:1995-03-07
标 题 :Catalytic enantioselective synthesis of a spirofused azetidinone

专利号:WO-9215579-A1
优先权日:1991-03-08
标 题 :Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
发明人：NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L
权利人:RHONE POULENC RORER INT
摘要:This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

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主要参考文献

[参考文献]: T Kaneda, Et Al. Aromatization Of 4-Oxocyclohexanecarboxylic Acid To 4-Hydroxybenzoic Acid By Two Distinctive Desaturases From Corynebacterium Cyclohexanicum. Properties Of Two Desaturases. Eur J Biochem. 1993 Dec 15;218(3):997-1003.

合成参考文献


摘要:Ayaz, M.; De Moliner, F.; Morales, G. A.; Hulme, C., Science of Synthesis: Multicomponent Reactions, (2013) 1, 118.
摘要:S. Siegel and J. M. Komarmy, J. Am. Chem. Soc. 82, 2547 (1960).
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