CAS: 71079-03-3; Dl-2-Amino-2-(4-Bromophenyl)Acetic Acid

该化合物是一种氨基酸衍生物,其特点是氨基酸的典型特征,一种氨基酸组和一个碳酸基酸组,这种化合物含有一种溴苯基组,具体地说是一种半溴苯基替代体,有助于其独特的化学特性;它通常是白色的,白色的,非白色的固体,由于存在氨基和碳本酸功能组,在水和酒精等极溶剂中可溶解.

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1260220-71-0 917925-71-4 1228570-47-5

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上下游产品

phenylglycin 1-bromo-4-(1-bromo-1-methoxycarbonyl)toluene sodium cyanide 4-bromo-benzaldehyde 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid methyl 2-amino-2-(4-bromophenyl)acetate hydr°Chloride methyl 6-bromo-(1H)-isoindolin-1-one-3-carboxylate methyl 2-is°Cyano-2-(4-bromophenyl)acetate

合成工艺路线路线简述

  • 2835-06-5 = 71079-03-3 + 254762-66-8 + 79422-73-4 + 500695-65-8 + 500695-66-9
    反应条件:1.1 Reagents: Sulfuric Acid,1,3,5-Triazine-2,4,6(1H,3H,5H)-Trione,1-Bromo-,Sodium Salt (1:1) Solvents: Water; 2.5 H,0 °C1.2 Reagents: Barium Hydroxide Solvents: Water; Ph 6 - 7
    标题:Chemistry Of Unprotected Amino Acids In Aqueous Solution: Direct Bromination Of Aromatic Amino Acids With Bromoisocyanuric Acid Sodium Salt Under Strong Acidic Condition
    作者:Yokoyama,Yuusaku; Yamaguchi,Tomotsugu; Sato,Masanori; Kobayashi,Eri; Murakami,Yasuoki; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:2006 卷标:54(12) 页码:1715-1719
📜2-(4-溴苯基)-2-氧代乙酸置于(S)-2-氯苯甘氨酸体系中,用 水,乙腈 作为反应溶剂,化学反应 36.0H,以62%的收率获得产物2-氨基-2-(4-溴苯基)乙酸
参考文献:通过2-(2-氯苯基)甘氨酸的芳基乙醛酸的氨基转移来合成未保护的2-芳基甘氨酸.
标题:通过2-(2-氯苯基)甘氨酸的芳基乙醛酸的氨基转移来合成未保护的2-芳基甘氨酸.
摘要:用2-苯基甘氨酸对α-酮酸进行氨基转移是直接合成未保护的α-氨基酸的有效方法.但是,通过氨基转移合成2-芳基甘氨酸是有问题的,因为相应的产物2-芳基甘氨酸使起始的芳基乙醛酸发生氨基转移.在此,我们展示了使用可商购获得的升-2-(2-氯苯基)甘氨酸作为在arylglyoxylic酸氨基转移氮源,在不脱离不希望的自转移方法干扰产生相应的2-芳基甘氨酸.
DOI:10.1021/acs.Joc.0C01302

海关参考信息

专利信息


专利号:EP-4225304-A1
优先权日:2020-10-12
标 题:Synthesis of egfr modulators

专利号:CN-116997551-A
优先权日:2020-10-12
标题 :Synthesis of EGFR modulators

专利号:US-2024018144-A1
优先权日:2020-10-12
标题:Synthesis of EGFR Modulators
发明人：RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
权利人:UNIV MICHIGAN REGENTS
摘要:Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A:

专利号:WO-2022077154-A1
优先权日:2020-10-12
标 题:Synthesis of egfr modulators
发明人：RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
权利人:UNIV MICHIGAN REGENTS; RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
摘要:Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A:

专利号:WO-2022081514-A1
优先权日:2020-10-12
标题:Synthesis of egfr modulators

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合成参考文献


参考文献:10.1038/s43018-021-00249-x
摘要:Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, Graves AP, Fairweather E, Werner T, Raoof A, Butlin RJ, Rueda L, Horton JR, Fosbenner DT, Zhang C, Handler JL, Muliaditan M, Mebrahtu M, Jaworski J, McNulty DE, Burt C, Eberl HC, Taylor AN, Ho T, Merrihew S, Foley SW, Rutkowska A, Li M, Romeril SP, Goldberg K, Zhang X, Kershaw CS, Bantscheff M, Jurewicz AJ, Minthorn E, Grandi P, Patel M, Benowitz AB, Mohammad HP, Gilmartin AG, Prinjha RK, Ogilvie D, Carpenter C, Heerding D, Baylin SB, Jones PA, Cheng X, King BW, Luengo JI, Jordan AM, Waddell I, Kruger RG, McCabe MT. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nature Cancer. 2021 Sep 27;2(10):1002–17. doi: 10.1038/s43018-021-00249-x.
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