CAS: 708-06-5; 2-Hydroxy-1-Naphthaldehyde

相似化合物

947-65-9 581-71-5 20258-95-1

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1-dimethylaminomethyl-naphthalen-2-ol 2-chloro-3H-indol-3-one β-naphthol hexamethylenetetramine 5-(2-hydroxy-[1]naphthylmethylene)-2-thioxo-thiazolidin-4-one (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)picolinohydrazide (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)nicotinohydrazide (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide

2-羟基-1-萘甲酸置于lithium Aluminium Tetrahydride,Pyridinium Chlorochromate体系中,用 乙醚,二氯甲烷 作为反应溶剂,化学反应 24.0H,反应生成 2-羟基-1-萘甲醛
参考文献:结构指导的合成和机理研究揭示了萘基水杨hy Hy支架上的亮点是人类核糖核苷酸还原酶的非核糖竞争性可逆抑制剂.
标题:结构指导的合成和机理研究揭示了萘基水杨hy Hy支架上的亮点是人类核糖核苷酸还原酶的非核糖竞争性可逆抑制剂.
摘要:核糖核苷酸还原酶(rr)是已确立的癌症靶标,通常被抗代谢物抑制,该抗代谢物表现出多种交叉反应作用.最近,我们发现了基于萘基水杨酰基的人rr(hrr)的抑制剂(nsah或e-3A)在催化位点(c-位)结合并可逆地抑制hrr.我们在此报告了25种不同类似物的合成和生化特性.我们基于2.7åx射线晶体结构(pdb Id:5Tus),通过对接至hrr的c位点设计了每个类似物.观测到对微小结构变化的广泛耐受性,从而保持了抑制效力.e-3F(82%的收率)显示了体外ic 50相对于hrr为5.3+/-1.8μm,使其在该系列中最有效.动力学测定表明,E-3A,E-3C,E-3T和e-3W通过可逆和竞争模式结合并抑制hrr.建立了对hrr R1亚基的目标选择性,为抑制这种关键酶提供了一种新颖的方法.
DOI:10.1021/acs.Jmedchem.7B00530

专利信息

专利号:US-5502126-A
优先权日:1993-06-17
标 题 :Process for the synthesis of isoprene butadiene rubber
发明人：BELL ANTHONY J; MATRANA BARRY A; HALASA ADEL F
权利人:GOODYEAR TIRE & RUBBER
摘要:The subject invention relates to a technique for synthesizing rubbery non-tapered, random, copolymers of 1,3-butadiene and isoprene. These rubbery copolymers exhibit an excellent combination of properties for utilization in tire sidewall rubber compounds for truck tires. By utilizing these isoprene-butadiene rubbers in tire sidewalls, tires having improved cut growth resistance can be built without sacrificing rolling resistance. Such rubbers can also be employed in tire tread compounds to improve tread wear characteristics and decrease rolling resistance without sacrificing traction characteristics. This invention more specifically discloses a process for the synthesis of isoprene-butadiene rubbers which comprises copolymerizing isoprene monomer and 1,3-butadiene monomer in an organic solvent in the presence of a catalyst system which is made by the sequential steps of (1) mixing (a) an organoaluminum hydride, (b) a member selected from the group consisting of aliphatic alcohols, cycloaliphatic alcohols, aliphatic thiols, cycloaliphatic thiols, trialkyl silanols, and triaryl silanols, and (c) optionally, 1,3-butadiene in an organic solvent to produce a modified organoaluminum catalyst component; (2) adding an organometallic compound which contains a metal from Group III-B of the Periodic System to the modified organoaluminum catalyst component to produce a Group III-B metal containing catalyst component; and (3) adding a compound which contains at least one labile halogen atom to the Group III-B metal containing catalyst component.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4369312-A
优先权日:1980-07-04
标 题:Method of producing oxo-containing azetidinone compounds
发明人：HASHIMOTO MASASHI; ARATANI MATSUHIKO; HAGIWARA DAIJIRO; SAWADA KOZO; ONAMI TETSUO
权利人:FUJISAWA PHARMACEUTICAL CO
摘要:This invention relates to a novel method of producing oxo-containing azetidinone compounds, or salts thereof, or hydrates thereof, said compounds having utility as antimicrobial agents and as intermediates for the synthesis of other azetidinone compounds having antimicrobial activity.

专利号:US-4197408-A
优先权日:1975-08-01
标 题 :Asymmetric synthesis of alkyl chrysanthemate
发明人：ARATANI TADATOSHI; FUJITA FUMIO; NAGASE TSUNEYUKI; YONEYOSHI YUKIO
权利人:SUMITOMO CHEMICAL CO
摘要:A process for the production of an optically active chrysanthemate which comprises reacting 2,5-dimethyl-2,4-hexadiene with a diazoacetate of the formula: n n N.sub.2 CHCOOR n n wherein R is selected from the group consisting of (a) cycloalkyl group with or without substituent(s) whose total carbon atom number is 5-20, (b) tertiary aralkyl group whose carbon atom number is 9 to 20, and (c) tertiary alkyl group with or without alkoxy substituent(s) whose total carbon atom number is 4-20, in the presence of a copper complex coordinated with a chiral Schiff base of the formula: ##STR1## wherein C* is an asymmetric carbon atom, R 1 is selected from the group consisting of (a) alkyl groups whose carbon atom number is 1-10 and (b) aralkyl groups with or without alkoxy substituent(s), whose total carbon atom number is 7-20, R 2 is selected from aryl groups with alkoxy substituent(s), whose total carbon atom number is 7-30, and each of X 1 and X 2 is selected from the group consisting of (a) hydrogen atom, (b) alkyl groups having 1-10 carbon atoms, (c) phenyl group, (d) alkoxy groups having 1-10 carbon atoms, (e) halogen atoms and (f) nitro group, or (g) X 1 and X 2 together form a benzo group.

专利号:US-4603218-A
优先权日:1983-06-03
标题 :Asymmetric synthesis of cyclopropanecarboxylate derivatives using chiral copper complex as catalyst
发明人：ARATANI TADATOSHI; YOSHIHARA HIROSHI; SUSUKAMO GOHFU
权利人:SUMITOMO CHEMICAL CO
摘要:A chiral copper complex which is produced by the reaction of a chiral copper complex of the formula: ##STR1## wherein R 1 is (a) alkyl group, or (b) aralkyl group; R 2 is (a) 2-alkoxyphenyl group, or (b) 2-alkoxy-5-alkylphenyl group; either one of X 1 and X 2 is (a) hydrogen atom, (b) halogen atom, (c) alkyl group, (d) alkoxy group, or (e) nitro group, or adjacent X 1 and X 2 together form a benzo group, with a mono-substituted hydrazine of the formula: n n R.sub.3 NHNH.sub.2 n n wherein R 3 is (a) aryl group, (b) aralkyl group, or (c) alkyl group. n The copper complex is used as a catalyst in the production of an optically active alkyl cyclopropanecarboxylate.