CAS: 6882-68-4; (41S,7Ar,13Ar,13Br)-Dodecahydro-1H-Dipyrido[2,1-F:3',2',1'-Ij][1,6]Naphthyridin-10(41H)-One

上下游产品

sophoridine N-oxide (3aS,6aR,11aR,11bR,11cS)-3a-Oxy-dodecahydro-3a,7a-diaza-benzo[de]anthracen-8-one4-((1R,3aR,3a1S,10aR)-2-(4-chlorobenzyl)decahydro-1H,4H-pyrido[3,2,1-ij][1,6]naphthyridin-1-yl)butan-1-ol 22H31FN2O2C22H31FN2O2 22H31FN2O2C22H31FN2O2 12-N-(4-fluorobenzyl)sophoridine butyric acid

📜Oxysophoridine置于escherichia Coli体系中,化学反应 36.0H,反应生成 槐定碱
参考文献:从土壤中分离出的微生物对氧杂环丁烷的区域选择性还原
标题:从土壤中分离出的微生物对氧杂环丁烷的区域选择性还原
摘要:氧化苦参碱(osr)是一种从中药中提取的生物碱,由于其出色的生物活性而受到越来越多的关注.研究了包括土壤微生物和内生真菌在内的86种污渍对osr的生物催化作用.将osr与鉴定为大肠杆菌的土壤细菌t003一起孵育只能产生一种具有高区域选择性的还原性产物.转化产物的结构阐明主要通过NMR光谱法和参考文献实现.研究了ph,底物浓度,转化时间和菌株浓度的影响,并通过lc-Ms分析了反应的最优化.在ph 7.0,温育36小时和分别存在625μg/ Ml底物浓度和50μl/ Ml菌株浓度的情况下,Osr产生的槐定碱(sr)最高.生物催化被认为是绿色和可持续的合成方法制备的槐定啶的替代方法,除了耗时少且对环境更友好.
DOI:10.1002/jccs.201500501

专利信息

专利号:CN-1654466-A
优先权日:2004-02-10
标 题 :Method for synthesis of oxidized dophoridine

专利号:CN-104531591-B
优先权日:2015-01-15
标 题:A bacterial strain capable of catalyzing the synthesis of sophoridine

专利号:CN-114717247-B
优先权日:2022-05-17
标 题:Cassava transcription factors MebHLH72 and MebHLH114 and application thereof in inhibiting synthesis of linolenyl bitter

专利号:CN-104611238-B
优先权日:2015-02-04
标题:A strain capable of catalyzing the synthesis of oxysophoridine

专利号:CN-104611238-A
优先权日:2015-02-04
标 题:A bacterial strain capable of catalyzing the synthesis of oxysophoridine

专利号:WO-2023241290-A1
优先权日:2022-06-13
标 题:Pharmaceutical compound based on quinolizidine derivative, and preparation method therefor and use thereof
发明人：YIN XIAOYING; WANG YANQING; LIU QINGSHAN; SHAN HONGLI; TANG LI; CHEN LINGYAN
权利人:UNIV SHANGHAI ENG SCIENCE
摘要:The present invention relates to the technical field of anti-tumor and anti-nerve-injury drug synthesis. Disclosed are an anti-tumor and anti-nerve-injury pharmaceutical compound based on a quinolizidine derivative, a use and a preparation method. Compared with the prior art, in the structural formula of the pharmaceutical compound provided by the present application, based on a natural quinolizidine alkaloid-isoflavone skeleton, structural modification is performed on an isoflavone part to obtain a series of derivatives, and experiments prove that the series of compounds can resist nerve injury, and has good application prospects in the aspect of preventing and treating nerve injury related diseases, wherein R2=R3=H; when R2 and R3 are functional groups which easily form a hydrogen bond, the series of compounds have anti-tumor activity and have application prospects. The present invention has the advantages that the preparation method is efficient and easy to operate, and the product has high purity and high activity.