CAS: 6795-23-9; (6Ar,9Ar)-9A-Hydroxy-4-Methoxy-2,3,6A,9A-Tetrahydrocyclopenta[c]Furo[3',2':4,5]Furo[2,3-H]Chromene-1,11-Dione

该化合物是真菌Aspergillus flavus 和 Asperglus mondicus 所生产的蛋白毒素,主要存在于受污染的乳制品中,特别是食用黄曲毒素B1的动物的奶制品中,主要是二代代新石,被归类为一种致癌物,特别与人类肝癌有关.黄曲霉素M1是一种极地化合物,溶于乙醇和乙酰三烯等有机溶剂中,但在水中较不易溶解.其化学结构有一个乳腺环和呋喃杂物,有助于其生物活动.由于该物质具有毒性和潜在健康风险,因此在许多国家受到管制,导致食物和饲料产品的允许水平受到严格限制.检测方法往往涉及高性液体色谱法以及荧光谱检测或大规模光谱测量.由于其稳定性,黄曲素M1可以持续存在于食品中,从而在食品安全实践中产生了监测和控制.

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CAS号30694-05-4 ethyl 2-bromo-5...

合成工艺路线路线简述

    📜3A-Acetoxy-4-(Benzyloxy)-6-Methoxy-3A,8A-Dihydrofuro<2,3-B>Benzofuran置于氨,Sodium Methylate,Sodium,碳酸氢钠,Zinc(II) Carbonate体系中,用 四氢呋喃,甲醇,乙醚,二氯甲烷 作为反应溶剂,化学反应 24.75H,反应生成 黄曲霉毒素 M1
    参考文献:New Synthesis Of Aflatoxin M1
    标题:New Synthesis Of Aflatoxin M1
    摘要:
    DOI:10.1021/ja00402A039

    海关参考信息

    专利信息


    专利号:US-11629150-B2
    优先权日:2016-07-01
    标题:Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
    发明人:SMITH ALEXANDER; WHITE HANNAH S; TAVARES FRANCIS XAVIER; KRASUTSKY SERGIY; CHEN JIAN-XIE; DORROW ROBERTA L; ZHONG HUA
    权利人:G1 THERAPEUTICS INC
    摘要:This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

    专利号:US-9890126-B2
    优先权日:2012-04-24
    标 题:Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF)
    发明人:HAGEN TIMOTHY J; ZHANG ZHENG; LAZOWSKI ZACHARY; CLARE MICHAEL; BEGLEY DARREN W
    权利人:UNIV NORTHERN ILLINOIS BOARD OF TRUSTEES; BERYLLIUM DISCOVERY CORP
    摘要:Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

    专利号:US-2015175582-A1
    优先权日:2012-04-24
    标 题:Design and synthesis of novel inhibitors of isoprenoid biosynthesis

    专利号:US-2016257655-A1
    优先权日:2012-04-24
    标 题:Design and synthesis of novel inhibitors of isoprenoid biosynthesis (ispf)

    专利号:US-9309232-B2
    优先权日:2012-04-24
    标 题:Synthesis of novel inhibitors of isoprenoid biosynthesis

    专利号:US-2021122755-A1
    优先权日:2016-07-01
    标 题:Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1080/19440040903403362
    摘要:Alonso VA, Monge MP, Larriestra A, Dalcero AM, Cavaglieri LR, Chiacchiera SM. Naturally occurring aflatoxin M(1) in raw bulk milk from farm cooling tanks in Argentina. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Mar;27(3):373–9. doi: 10.1080/19440040903403362.
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