CAS: 65678-07-1; 2-(3-Bromo-5-(Tert-Butyl)-4-Hydroxybenzylidene)Malononitrile

上下游产品

3-bromo-5-tert-butyl-4-hydroxybenzaldehyde malononitrile 2-tert-Butylphenol 3-(1,1-Dimethylethyl)-4-hydroxy-benzaldehyde

📜3-(叔丁基)-4-羟基苯甲醛置于溴体系中,用 溶剂黄146 作为反应溶剂,化学反应生成 2-[[3-溴-5-叔丁基-4-羟基苯基]亚甲基]丙二腈
参考文献:Compositions For Killing Internal Parasites Containing
标题:Compositions For Killing Internal Parasites Containing
摘要:通式i的化合物##str1##其中r.Sup.1是卤素,R.Sup.4是高度分支的烷基基团,R.Sup.2和r.Sup.3可以相同也可以不同,是氢或卤素原子或低烷基基团.

专利信息

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.