CAS: 638-56-2; Bis[2-(2-Chloroethoxy)Ethyl] Ether

相似化合物

5197-65-9 112-26-5 5197-62-6

上下游产品

戊乙二醇二氯化物 1,14-Dichloro-3,6,9,12-Tetraoxatetradecane 5197-65-9
三缩四乙二醇 Tetraethylene Glycol 112-60-7

2,5,8,11,14-Pentaoxa-Pentadecanedioyl Chloride置于hexabutylguanidinium Chloride体系中,化学反应 4.0H,以81%的收率获得产物双[2-(2-氯化乙氧基)乙基]醚
参考文献:通过催化分解相应的烷基和烷氧基烷基氯甲酸酯和双氯甲酸酯与六丁基亚砜来制备烷基和烷氧基烷基氯化物和二氯化物的安全有效方法
标题:通过催化分解相应的烷基和烷氧基烷基氯甲酸酯和双氯甲酸酯与六丁基亚砜来制备烷基和烷氧基烷基氯化物和二氯化物的安全有效方法
摘要:少量六丁基氯化胍 (0.01 Mol%) 通过半连续过程分解具有不同长度碳链的纯氯甲酸酯或双氯甲酸酯,以降低失控风险,从而产生高产率和纯度的氯化物化合物.
DOI:10.1081/scc-100000525

专利信息

专利号:US-7923584-B2
优先权日:2008-01-23
标题 :Synthesis of difunctional oxyethylene-based compounds
发明人：HOLMES BRIAN T; SNOW ARTHUR W
权利人:US NAVY
摘要:A method of reacting a toluenesulfonyl-terminated polyoxyethylene compound having the formula CH 3 —C 6 H 4 —SO 2 —(O—CH 2 —CH 2 ) n —O—R 1 with an ammonium salt having the formula NR 2 4 X to form a compound having the formula X—CH 2 —CH 2 —(O—CH 2 —CH 2 ) n-1 —R 3 . The value n is a positive integer. X is a halogen, cyanide, cyanate, thiocyanate, or azide. R 1 is a terminating group. Each R 2 is hydrogen or an alkyl group. —R 3 is —O—R 1 or —X.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-9889182-B2
优先权日:2009-09-15
标 题 :Assisted enzyme replacement therapy
发明人：ESKO JEFFREY D; TOR YITZHAK
权利人:ESKO JEFFREY D; TOR YITZHAK; UNIV CALIFORNIA
摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

专利号:US-2009187037-A1
优先权日:2008-01-23
标题:Synthesis of difunctional oxyethylene-based compounds

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.