CAS: 626-97-1; Pentanamide

该化合物是化学配方C5H11NO的有机化合物.它属于氨化物类别,其特点是存在碳基(C=O)直接与氮原子结合(N). Pentanamide在室温下是没有色的,可粉黄黄色液体,并且有轻微的类似粒子的气味.它由于能形成氢结,在水和极地有机溶剂中可以溶解.该化合物与类似分子重量的碳氢化合物相比,具有相对较高的沸点,反映了强烈的中间分子力量. Pentanamide被用于各种应用,包括作为溶剂,药物合成和有机合成的中间体.其特性使它在工业和实验室环境中都是一种有用的化合物.安全数据表明,它与许多亚胺一样,应该谨慎处理,因为它可能会引起皮肤和接触时眼睛的刺激.

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CAS号110-59-8 戊腈 | CAS号110-62-3 正戊醛 | CAS号109-52-4 正戊酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号638-29-9 正戊酰氯 | CAS号84298-28-2 1H-1,2,3-benzot... | CAS号71-41-0 正戊醇 | CAS号144150-84-5 N-pentanoyl-4-m... | CAS号4307-07-7 N-tert-butylpen... | CAS号67015-06-9 N-HYDROXY-PENTA... | CAS号10601-69-1 N-acetylpentanamide | CAS号542-28-9 δ-戊内酯 | CAS号109-73-9 正丁胺 | CAS号108-29-2 丙位戊内酯 | CAS号71-41-0 正戊醇 | CAS号110-58-7 1-氨基戊烷 | CAS号109-52-4 正戊酸 | CAS号110-59-8 戊腈 | CAS号111-71-7 正庚醛 | CAS号123-15-9 2-甲基戊醛

合成工艺路线路线简述

    正戊酸置于ammonium Hydroxide,三乙胺体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 1.08H,反应生成 戊酰胺
    参考文献:通过可见光光氧化还原催化对羧酸衍生物进行定向 γ-C(Sp3)-H 烷基化
    标题:通过可见光光氧化还原催化对羧酸衍生物进行定向 γ-C(Sp3)-H 烷基化
    摘要:可见光光氧化还原催化可实现饱和脂肪族羰基化合物的直接 γ-C(Sp3)-H 烷基化.缺电子烯烃用作该反应中的偶联伙伴.显着的位点选择性由原位产生的酰胺基的主要 1,5-氢原子转移控制.
    DOI:10.1021/jacs.7B09306

    海关参考信息

    专利信息


    专利号:US-10253153-B2
    优先权日:2015-04-24
    标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
    发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
    权利人:NITTO DENKO CORP
    摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6281367-B1
    优先权日:1998-03-20
    标 题:Process for the synthesis of HIV protease inhibitors
    发明人:AL-FARHAN EMILE; DEININGER DAVID D; MCGHIE STEPHEN; O'CALLAGHAN JOHN; ROBERTSON MARK STUART; RODGERS KEITH; ROUT STEPHEN JOHN; SINGH HARDEW; TUNG ROGER DENNIS
    权利人:GLAXO WELLCOME INC
    摘要:An improved process for the synthesis of (3S)-tetrahydro-3-furyl N-[(1S,2R)-3 -(4-amino-N-isobutylbenzenesulphonamido)-1-benzyl-2-hydroxypropyl]carbamate comprising four steps form the compound of formula A and a novel intermediate thereto.

    专利号:WO-0172706-A1
    优先权日:2000-03-28
    标题 :Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
    发明人:SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
    权利人:BIOCON LTD; SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
    摘要:The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt by using 4-fluoro-α-[2-methyl-1-oxopropyl]η-oxo-N-β-diphenylbenzene butaneamide with (4R)-methyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-3-acetate. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and are thus used as hypolipidemic and hypocholesterolemic agents.

    专利号:US-2002037834-A1
    优先权日:2000-09-08
    标题 :Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
    发明人:ASTATKE MEKBIB; GEBEYEHU GULILAT
    权利人:INVITROGEN CORP
    摘要:The present invention relates to cationic and polycationic compositions and methods for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses cationic and polycationic molecules, compounds, and compositions having affinity for double-stranded and/or single-stranded nucleic acid molecules and/or single-stranded/double-stranded nucleic acid complexes (e.g., primer/template complexes, double-stranded templates, single-stranded templates or single-stranded primers) for use in such enhanced synthesis. The cationic and polycationic molecules, compounds, and compositions of the invention are capable of inhibiting nonspecific nucleic acid synthesis at ambient temperature. Thus, in a preferred aspect, the invention relates to “hot startâ€? synthesis of nucleic acid molecules. Accordingly, the invention prevents non-specific nucleic acid synthesis at low temperatures, for example during reaction set up. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the cationic and polycationic molecules, compounds, and compositions of the invention. The invention also relates to compositions prepared for carrying out the methods of the invention and to compositions made after or during such methods. The invention also generally relates to compositions useful for inhibiting or preventing degradation of various nucleic acid molcules.
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    主要参考文献

    参考标题:Transamidation For The Synthesis Of Primary Amides At Room Temperature
    作者:Jiajia Chen,Yuanzhi Xia,Sunwoo Lee |发布日期:2020.5.1
    摘要:Various Primary Amides Have Been Synthesized Using The Transamidation Of Various Tertiary Amides Under Metal-Free And Mild Reaction Conditions. When (Nh4)2Co3 Reacts With A Tertiary Amide Bearing An N-Electron-Withdrawing Substituent, Such As Sulfonyl And Diacyl, In Dmso At 25 °C, The Desired Primary Amide Product Is Formed In Good Yield With Good Funcctional Group Tolerance. In Addition, N-Tosylated

    合成参考文献


    摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 203.
    参考文献:10.1007/s00775-004-0549-9
    摘要:Duin EC, Signor L, Piskorski R, Mahlert F, Clay MD, Goenrich M, Thauer RK, Jaun B, Johnson MK. Spectroscopic investigation of the nickel-containing porphinoid cofactor F430. Comparison of the free cofactor in the +1, +2 and +3 oxidation states with the cofactor bound to methyl-coenzyme M reductase in the silent, red and ox forms. JBIC Journal of Biological Inorganic Chemistry. 2004 May 25;9(5):563–76. doi: 10.1007/s00775-004-0549-9.
    参考文献:10.1385/ep:13:1:39
    摘要:Lam KY. Autopsy findings in diabetic patients: a 27-yr clinicopathologic study with emphasi on opportunistic infections and cancers. Endocr Pathol. 2002;13(1):39–45. doi: 10.1385/ep:13:1:39.
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