CAS: 61718-80-7; 5-Methoxy-1-(4-(Trifluoromethyl)Phenyl)Pentan-1-One

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CAS号4457-67-4 1-溴-4-甲氧基丁烷 | CAS号455-18-5 对三氟甲基苯腈 | CAS号106-93-4 1,2-二溴乙烷 | CAS号634590-61-7 magnesium,1-met...

对三氟甲基苯腈置于magnesium,Sodium Hydroxide,碘甲烷体系中,用 四氢呋喃 作为反应溶剂,化学反应 25.0H,反应生成 5-甲氧基-1-[4-(三氟甲基)苯基]-1-戊酮
参考文献:1-对三氟甲苯基-5-甲氧基-戊酮的合成方法
标题:1-对三氟甲苯基-5-甲氧基-戊酮的合成方法
摘要:本发明公开了一种1‑对三氟甲苯基‑5‑甲氧基‑戊酮的合成方法,具体合成过程如下:向反应容器中加入氢氧化钠溶液,升温至70‑80oc后加入对三氟甲基苯腈搅拌反应10H后降温至65°C,然后向反应容器中加入甲醇溶液搅拌反应2H后冷却至室温,然后进行分液,取有机相即为对三氟甲基苯甲酸甲酯;氮气的保护下,在烧瓶中加入无水四氢呋喃和镁屑,并加入几滴碘甲烷,升温至75°C,搅拌溶解后逐滴加入1‑氯‑4‑甲氧基丁烷,滴加完毕后恒温反应13H,降温至室温后逐滴加入步骤1中制备的对三氟甲基苯甲酸甲酯得到产物.本发明制备的对三氟甲基苯甲酸甲酯与对三氟甲基苯腈相比,在与格式试剂反应过程中反应条件温和,并且反应过程容易控制,反应更彻底,产物的产率高.

专利信息

专利号:US-2009264680-A1
优先权日:2004-07-07
标题:Process for the synthesis and purification of (4-methoxybutyl) (4-trifluoromethylphenyl) methanone
发明人：CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
权利人:CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
摘要:A process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the organomagnesium specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.

专利号:US-6380436-B1
优先权日:1998-05-12
标 题 :Process for the synthesis of alkoxyalkyl (trifluormethylphenyl) methanones
发明人：THENNATI RAJAMANNAR; DEO KESHAV; MIDHA AJAY SOHANLAL; CHANDRA TILAK; PATEL VIJAY MULJIHHAI
权利人:SUN PHARMACEUTICAL IND LTD
摘要:A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.

专利号:WO-9958485-A1
优先权日:1998-05-12
标 题:A process for the synthesis of alkoxyalkyl (trifluoromethylphenyl) methanones

专利号:CN-101602658-B
优先权日:2009-07-14
标 题:Synthesis of 5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone

专利号:CH-691180-A5
优先权日:1998-05-12
标题:A process for the synthesis of alkoxyalkyl (trifluoromethylphenyl) -Methanonen.

专利号:IL-180512-A0
优先权日:2004-07-07
标 题:Process for the synthesis and purification of (4-methoxybutyl)(4-trifluoromethylphenyl)methanone