CAS: 508-02-1; (4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid

上下游产品

sodium ethanolate methanol oleanolic acid methyl ester sodium acetateoleanolic acid methyl ester 1,2,7-trimethylnaphthalene erythrodiol 28-nor-olean-17-en-3β-ol

3-O-[β-D-Xylopyranosyl-(1->4)-β-D-Galactopyranosyl]Oleanolic Acid置于盐酸体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 齐墩果酸
参考文献:Polyacanthoside A,一种新型的齐墩果型三萜皂苷,对洋槐叶(fabaceae)的叶片具有细胞毒性作用.
标题:Polyacanthoside A,一种新型的齐墩果型三萜皂苷,对洋槐叶(fabaceae)的叶片具有细胞毒性作用.
摘要:对金合欢(fabaceae)的叶子和茎皮进行化学研究后,分离出了一种名为聚棘皮苷a 1的新型齐墩果型三萜皂苷和十五种已知化合物.它们的结构由光谱,主要是hresims,1D NMR和2D NMR建立,并与文献数据进行比较.在包括敏感和耐药表型的9种癌细胞系中确定了化合物1和类似物8以及阿霉素的细胞毒性.与类似物8不同,化合物1和阿霉素在所有9种测试的ic 50癌细胞系中均显示出细胞毒性作用化合物1的值范围从8.90μm(对ccrf-Cem白血病细胞)到35.21μm(对hepg2肝癌细胞),对于阿霉素,范围从0.02μm(对ccrf-Cem白血病细胞)到66.83μm(对cem / Adr5000白血病细胞). .
DOI:10.1080/14786419.2018.1486312

专利信息

专利号:US-9943544-B2
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
发明人：BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.

专利号:US-7700654-B2
优先权日:2005-02-05
标 题:Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma
发明人：HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA
权利人:LOHMANN THERAPIE SYST LTS
摘要:A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.

专利号:US-2014206842-A1
优先权日:2013-01-22
标题:Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; CHANDRAMOULI RENUKESHWAR H; SOOD RATTAN; PRAKASH SUBBALAKSHMI; ANAND SUSMITHA
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; CHANDRAMOULI RENUKESHWAR H; SOOD RATTAN; PRAKASH SUBBALAKSHMI; ANAND SUSMITHA
摘要:The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the Synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.

专利号:US-8383594-B2
优先权日:2007-08-07
标题:Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceuticals
发明人：MAJEED MUHAMMED; CHANDRAMOULI RENUKESHWAR H; NAGABHUSHANAM KALYANAM; SOOD RATTAN; PRAKASH SUBBALAKSHMI; ANAND SUSMITHA
权利人:SAMI LABS LTD; MAJEED MUHAMMED; CHANDRAMOULI RENUKESHWAR H; NAGABHUSHANAM KALYANAM; SOOD RATTAN; PRAKASH SUBBALAKSHMI; ANAND SUSMITHA
摘要:The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.

专利号:US-2023157936-A1
优先权日:2021-11-24
标 题 :Anti-aging skin peel composition and method of application
发明人：ZAHR ALISAR; NGUYEN THU Q; KOCH JOHN; KELLY TATIANA
权利人:JAMRM LLC
摘要:A skincare composition and a method for removing layers of skin in a cosmetic procedure. The skincare composition comprises active ingredients mixed into a cosmetically acceptable carrier. The active ingredients include an effective amount of one or more keratolytic agents for inducing a desired degree of keratolysis in the skin, an effective amount of one or more free radical neutralizing agents for negating cellular damage from reactive chemical species, and an effective amount of one or more agents increasing synthesis of dermal components. The one or more free radical neutralizing agents and the one or more agents increasing synthesis of dermal components are acids in their un-neutralized, natural acid form, and a total amount of the active ingredients is less than 50 w/w% of the skincare composition, and a pH of the skincare composition is between 1.5-3.5.

专利号:US-8067465-B2
优先权日:2002-01-15
标题:Tricyclic-bis-enone derivatives and methods of use thereof
发明人：HONDA TADASHI; FAVALORO FRANK G; GRIBBLE GORDON W; SPORN MICHAEL B; SUH NANJOO
权利人:HONDA TADASHI; FAVALORO FRANK G; GRIBBLE GORDON W; SPORN MICHAEL B; SUH NANJOO; DARTMOUTH COLLEGE
摘要:Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.