CAS: 486422-58-6; (4-(Piperidin-1-Ylsulfonyl)Phenyl)Boronic Acid

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4-bromobenzenesulfonyl chloride 1-((4-bromophenyl)sulfonyl)piperidine piperidine {6-chloro-3-methyl-4-[4-(piperidine-1-sulfonyl)-phenyl]-naphthalen-2-yl}-acetic acid methyl ester {6-fluoro-3-methyl-4-[4-(piperidine-1-sulfonyl)-phenyl]-naphthalen-2-yl}-acetic acid methyl ester ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

📜1-(4-溴苯基磺酰)哌啶置于正丁基锂,水,Silica Gel体系中,用 四氢呋喃 作为反应溶剂,化学反应 18.0H,反应生成 4-(哌啶-1-基磺酰)苯基硼酸
参考文献:Discovery Of Novel Potent And Highly Selective Glycogen Synthase Kinase-3β (Gsk3β) Inhibitors For Alzheimer's Disease: Design,Synthesis,And Characterization Of Pyrazines
标题:Discovery Of Novel Potent And Highly Selective Glycogen Synthase Kinase-3β (Gsk3β) Inhibitors For Alzheimer's Disease: Design,Synthesis,And Characterization Of Pyrazines
摘要:Glycogen Synthase Kinase-3 Beta,Also Called Tau Phosphorylating Kinase,Is A Proline-Directed Serine/threonine Kinase Which Was Originally Identified Due To Its Role In Glycogen Metabolism. Active Forms Of Gsk3 Beta Localize To Pretangle Pathology Including Dystrophic Neuritis And Neurofibrillary Tangles In Alzheimer'S Disease (Ad) Brain. By Using A High Throughput Screening (Hts) Approach To Search For New Chemical Series And Cocrystallization Of Key Analogues To Guide The Optimization And Synthesis Of Our Pyrazine Series,We Have Developed Highly Potent And Selective Inhibitors Showing Cellular Efficacy And Blood-Brain Barrier Penetrance. The Inhibitors Are Suitable For In Vivo Efficacy Testing And May Serve As A New Treatment Strategy For Alzheimer'S Disease.
DOI:10.1021/jm201724M