📜1-氯己烷置于氢氧化钾,氯化亚砜,N,N-二甲基甲酰胺,Potassium Iodide体系中,用 乙醇,二氯甲烷,水 作为反应溶剂,化学反应 11.0H,反应生成 4-已氧基苯甲酰氯 参考文献:Synthesis Of Novel Discotic Mesogen Containing Electron-Transportable Oxadiazole Moiety 标题:Synthesis Of Novel Discotic Mesogen Containing Electron-Transportable Oxadiazole Moiety 摘要:We Synthesized And Characterized A Novel Discotic Liquid Crystalline Material (Mod) Composed Of 1,3,5-Tri-Substituted Benzene Core And 2-(4-Hexyloxyphenyl)-Oxadiazol-5-Yl Arms. Chemical Structure Of Thob Was Characterized Using H-1-NMR And Mass Spectroscopy And Its Thermal Behavior Was Determined. Using Dsc And Polarized Optical Microscopy. Thob Showed Narrow Mesophase Region At Around 128 Degreesc And Exhibited Nernatic-Like Texture. DOI:10.1080/10587250108030113
专利号:US-9662318-B2 优先权日:2012-07-16 标题 :Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof 发明人:BOULOS JOHN 权利人:BARRY UNIV INC 摘要:Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M 1 , M 2 , M 3 , M 4 , M 5 ) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. Additional bitopic muscarinic antagonists discovered and described herein include BK-23, HD-42, HD153, HD-185, KH-5, JM-31 and JM-32. These bitopic ligands and their structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M 1 -M 5 acetylcholine receptors.
专利号:US-2016136145-A1 优先权日:2012-07-16 标 题:Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
参考文献:10.1007/s002890070053 摘要:Hernndez SA, Zhou Q, Garay RO, Yang Y. Steric and electronic effects on mesophase stability of segmented liquid crystalline polymers with arylazomethine pendant groups. Polymer Bulletin. 2000 Sep 21;45(1):31–8. doi: 10.1007/s002890070053. 参考文献:10.1134/s1070427208090243 摘要:Novikova NS, Kilimenchuk ED, Yarkova MY, Meshkova SB, Topilova ZM. Synthesis and mesomorphism of 1,3-benzenedicarboxylic acid derivatives. Russian Journal of Applied Chemistry. 2008 Sep;81(9):1602–7. doi: 10.1134/s1070427208090243.