CAS: 37942-01-1; 5-Bromo-2-Methoxyphenol

上下游产品

CAS号90-05-1 愈创木酚 | CAS号25016-01-7 5-溴-2-甲氧基苯甲醛 | CAS号98910-57-7 methanesulfonic... | CAS号21702-84-1 2,4-二溴苯甲醚 | CAS号871571-19-6 5-溴-2-甲氧基苯基甲磺酸盐 | CAS号66037-04-5 acetic acid,5-b... | CAS号531-37-3 苯甲酸2-甲氧基苯酯 | CAS号613-70-7 邻甲氧基苯乙酸酯 | CAS号109971-64-4 3-methoxy-6-[2-... | CAS号516465-82-0 3-异丙氧基-4-甲氧基苯硼酸 | CAS号185244-57-9 2-(5-bromo-2-me... | CAS号185244-58-0 4-bromo-1-metho... | CAS号2859-78-1 3,4-二甲氧基溴苯 | CAS号85416-73-5 (S)-(+)-咯利普兰 | CAS号61413-54-5 咯利普兰 | CAS号52849-52-2 4-溴-2-乙氧基-1-甲氧基苯 | CAS号109971-63-3 康普瑞汀A-1 | CAS号177329-71-4 2-(叔丁基二甲基甲硅烷基氧基...

木榴油置于吡啶,甲醇,N-溴代丁二酰亚胺(Nbs),碳酸氢钠体系中,用 乙腈 作为反应溶剂,化学反应 22.0H,反应生成 5-溴-2-甲氧基苯酚
参考文献:格氏试剂铜催化炔丙基取代合成对映体富集形式的 Tnf 抑制剂,氟比洛芬和 I-Pr 类似物
标题:格氏试剂铜催化炔丙基取代合成对映体富集形式的 Tnf 抑制剂,氟比洛芬和 I-Pr 类似物
摘要:由 Tmsc Cch(Oh)Ch 2 CH2Otbdps 衍生的磷酸二乙酯与 3-C-C 5 H 9-4-Meoc 6 H 3 Mgbr在铜催化下发生取代反应,然后进行多次转化,得到肿瘤坏死因子抑制剂具有ph-乙炔部分.该抑制剂也由磷酸苯乙炔phc Cch(Op(O)(Oet) 2)Ch 2 CH2Otbdps合成.此外,衍生自 Tmsc Cch(Oh)Ch 3和 Tmsc Cch(Oh)-I-Pr 的磷酸盐被 3-F-4-Phc 6 H取代3 Mgbr 得到相应的替代产物,分别转化为氟比洛芬及其i-Pr 类似物.这些合成中的铜催化取代以区域选择性和立体选择性方式进行.
DOI:10.1039/d1Ob01944A

专利信息

专利号:US-8975431-B2
优先权日:2010-05-19
标 题 :Process for preparing an ortho-substituted 5-halophenol and a synthesis intermediate thereof
发明人：MERCIER CLAUDE; DE CAMPO FLORYAN; RIGHINI SÉBASTIEN
权利人:MERCIER CLAUDE; DE CAMPO FLORYAN; RIGHINI SÉBASTIEN; RHODIA OPERATIONS; SOLVAY CHINA CO LTD
摘要:A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl.

专利号:WO-2025138812-A1
优先权日:2023-12-29
标 题:Scaled-up preparation method for advantame
发明人：REN SHIKUO; LI TAO; ZENG GUOHUA; LI TING; XIONG SHENG
权利人:SHANGHAI ZAIQI BIO TECH CO LTD
摘要:The present invention belongs to the field of organic synthesis, and discloses a scaled-up preparation method for advantame. Two methods are used. Method A: taking acrolein and bis(pinacolato)diboron as raw materials, and reacting same in an aqueous solution under the catalysis of a copper salt and an organic alkali, so as to obtain 3-boric acid pinacol ester propionaldehyde; and then reacting same with 5-bromo-2-methoxyphenol in the presence of a palladium catalyst and an alkali, so as to generate 3-hydroxy-4-methoxybenzene propionaldehyde. Method B: performing a Grignard exchange on 5-bromine-2-methoxyphenol, and then reacting same with boric acid ester, so as to obtain 3-hydroxy-4-methoxyphenylboronic acid; and then reacting same with acrolein in the presence of a rhodium catalyst and an alkali, so as to generate 3-hydroxy-4-methoxybenzene propionaldehyde. Finally, reduction and ammoniation are performed to obtain advantame. The method reduces the amount of isomers produced and improves the reaction yield, the process is simple and reliable, the method is convenient for industrial production, and a new reaction path is provided for the synthesis of advantame.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:US-7807709-B2
优先权日:2005-03-23
标题 :Organic compounds
发明人：EHRHARDT CLAUS; IRIE OSAMU; LORTHIOIS EDWIGE LILIANE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER
权利人:NOVARTIS AG
摘要:The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis.

专利号:CN-113666812-A
优先权日:2021-09-10
标题 :Synthesis method of 5-halogenated veratraldehyde

专利号:CN-113666812-B
优先权日:2021-09-10
标 题 :Synthesis method of 5-halogenated veratraldehyde