CAS: 32133-39-4; 2,6-Difluoro-Dl-Phenylalanine

该化合物是苯丙胺的氟化衍生物,其特点是在芳香环的2和6个位置用氟代替氢原子,这一修改增强了其在药用化学和生化研究中的效用,特别是在发展酶抑制剂和基于的治疗方法方面的效用;氟原子的存在提高了代谢稳定性和结合性,使其对结构-活动关系研究具有价值;其种族形式(DL)允许在合成应用中广泛适用;该化合物通常被用作氟化模拟剂设计中的建筑块,用于检测生物系统或优化药物候选者.

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1235005-44-3 33787-05-2 266360-62-7

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    专利信息


    专利号:US-10087221-B2
    优先权日:2013-03-21
    标题 :Synthesis of hydantoin containing peptide products
    发明人：HENKEL BERND
    权利人:SANOFI AVENTIS DEUTSCHLAND
    摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

    专利号:US-9206222-B2
    优先权日:2009-06-29
    标题:Solid phase peptide synthesis of peptide alcohols
    发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
    权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
    摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

    专利号:US-8546533-B2
    优先权日:2008-08-29
    标 题:Pipecolic linker and its use for chemistry on solid support
    发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
    权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
    摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

    专利号:WO-2011000848-A1
    优先权日:2009-06-29
    标题 :Solid phase peptide synthesis of peptide alcohols

    专利号:US-2012108748-A1
    优先权日:2009-06-29
    标 题:Solid phase peptide synthesis of peptide alcohols

    专利号:EP-2448956-B1
    优先权日:2009-06-29
    标题:Solid phase peptide synthesis of peptide alcohols

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