CAS: 30675-13-9; 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-Dione

该化合物是一种有机化合物,其特点是结构复杂,包括一个由四氯原子和两组碳基(氯酮)替代的异烷核心,该化合物一般在室温下是固体,具有高度氯化,对其化学反应和物理特性有重大影响;多种氯原子的存在会增加其亲脂性,并可能传播生物活动,使其在各个领域,包括农业化学品和药品中引起兴趣;该化合物在标准条件下可能保持稳定,但可能会发生典型的碳基化合物反应,如核生殖器添加或替代;其有机溶解剂中的溶性以及水溶性有限是氯化有机化合物的常见特性;应当参考安全数据,因为氯化化合物可能对环境和健康造成危害.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

tetrachlorophthalic anhydride ethyl acetoacetate2-Benzhydryl-4,5,6,7-tetrachlor-1,3-indandion

合成工艺路线路线简述

    📜四氯苯二甲酸酐 反应生成 4,5,6,7-四氯茚满-1,3-二酮
    参考文献:Anti-Allergic Pharmaceutical Compositions
    标题:Anti-Allergic Pharmaceutical Compositions
    摘要:2-硝基茚并-1,3-二酮衍生物在预防和治疗哮喘,花粉热以及鼻炎方面具有用途.

    海关参考信息

    专利信息


    专利号:US-2013267680-A1
    优先权日:2010-09-15
    标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
    发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
    权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
    摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

    专利号:ES-2901551-T3
    优先权日:2005-12-01
    标 题 :Enzymatic Encoding Methods for Efficient Synthesis of Large Libraries

    专利号:WO-2012036551-A1
    优先权日:2010-09-15
    标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof

    专利号:EP-2616479-A1
    优先权日:2010-09-15
    标 题 :Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof

    专利号:ES-2651450-T3
    优先权日:2005-12-01
    标 题 :Enzymatic coding methods for efficient synthesis of large libraries

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    主要参考文献

    1. Mason, D.E., Ek, J., Peters, E.C., et al. Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry. Biochemistry 43(21), 6535-6544 (2004). 2. Setsuie, R., Sakurai, M., Sakaguchi, Y., et al. Ubiquitin dimers control the hydrolase activity of UCH-L3. Neurochemistry International 54(5-6), 314-321 (2009). 3. Wada, H., Kito, K., Caskey, L.S., et al. Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochemical and Biophysical Research Communications 251(3), 668-692 (1998). 4. Iphöfer, A., Kummer, A., Nimtz, M., et al. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. ChemBioChem 13(10), 1416-1420 (2012). 5. Liu, Y., Lashuel, H.A., Choi, S., et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & Biology 10(9), 837-846 (2003).

    合成参考文献


    参考文献:10.1371/journal.pone.0002585
    摘要:Si X, Gao G, Wong J, Wang Y, Zhang J, Luo H. Ubiquitination Is Required for Effective Replication of Coxsackievirus B3. PLoS ONE. 2008 Jul 09;3(7):e2585. doi: 10.1371/journal.pone.0002585.
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