CAS: 26537-19-9; Methyl 4-(Tert-Butyl)Benzoate

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CAS号67-56-1 甲醇 | CAS号877-65-6 4-叔丁基苄醇 | CAS号1184731-46-1 1-(tert-butyl)-... | CAS号3972-65-4 对叔丁基溴苯 | CAS号201230-82-2 carbon monoxide | CAS号98-51-1 4-叔丁基甲苯 | CAS号186581-53-3 重氮甲烷 | CAS号124-38-9 二氧化碳 | CAS号76471-78-8 4,4-二叔丁基苯偶酰 | CAS号43100-38-5 对叔丁基苯甲酰肼 | CAS号39528-62-6 4-叔丁基苯甲酰乙腈 | CAS号306936-90-3 5-(4-正丁基苯基)-1,3... | CAS号32857-63-9 4-叔丁基苯乙酸 | CAS号3288-99-1 对叔丁基苯乙腈 | CAS号23853-82-9 Benzenemethanol... | CAS号19692-45-6 4-叔丁基苄氯 | CAS号877-65-6 4-叔丁基苄醇 | CAS号69480-15-5 5-[4-(叔丁基)苯基]-1... | CAS号70356-09-1 阿伏苯宗

4-叔丁基甲苯置于三(2,4-二溴苯基)胺 Sodium Methylate,Lithium Perchlorate体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应生成对叔丁基苯甲酸甲酯
参考文献:烷基芳族化合物的间接电化学侧链氧化-苯甲酸甲酯或原苯甲酸三甲酯的选择性合成
标题:烷基芳族化合物的间接电化学侧链氧化-苯甲酸甲酯或原苯甲酸三甲酯的选择性合成
摘要:烷基芳族化合物从苯甲酸甲酯或原苯甲酸三甲酯到酯的技术上重要的侧链氧化反应可在甲醇溶液中以低电位通过电化学反应使用三元(2,4-二溴代苯胺)胺作为氧化还原催化剂在低电位下进行.在中性或弱酸性条件下,选择性地生成苯甲酸甲酯,而在碱性条件下,原酸酯占主导.以类似的方式从苯甲醛二甲基乙缩醛选择性地形成邻苯甲酸三甲酯.氧化还原催化剂在反应条件下是稳定的,因此可以进行数千个循环而没有明显的损失.
Doi:10.1016/s0040-4020(01)87454-8

专利信息

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-9856275-B2
优先权日:2013-02-12
标 题:Synthesis and use of fluorinated compounds
发明人：MOLANDER GARY ALAN; ARGINTARU OANA ANDREEA
权利人:UNIV PENNSYLVANIA
摘要:The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of reacting compounds of structure with R f —CHâ•?N 2 or (CF 3 ) 2 Câ•?N 2 to form a perfluoroalkylate or -arylated compounds, and products derived from these reactions, where X, Y B , and R f are described herein.

专利号:US-2011183958-A1
优先权日:2008-10-17
标 题 :Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; TRANMER GEOFFREY K
权利人:MERCK FROSST CANADA LTD
摘要:Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.

专利号:US-2014288324-A1
优先权日:2011-07-22
标 题:Method of regioselective synthesis of substituted benzoates

专利号:CN-112679346-A
优先权日:2021-01-22
标题 :A kind of method based on catalyzed synthesis of methyl p-tert-butyl benzoate based on deep eutectic solvent

专利号:US-7671085-B2
优先权日:2002-11-15
标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof
发明人：DOWNES MICHAEL R; EVANS RONALD M
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.