CAS: 2629-59-6; S-Ethyl-L-Cysteine

相似化合物

200354-34-3 16947-82-3 3262-64-4

上下游产品

ethyl bromide L-Cysteine diethyl sulfate ethyl iodideS-ethyl-L-cysteine sulfoxide N-(N-acetyl-sulfanilyl)-S-ethyl-L-cysteineN-(N-acetyl-sulfanilyl)-S-ethyl-L-cysteine -S-ethyl-L-cysteineN-3-(acetylthio)-2-benzylpropanoyl-S-ethyl-L-cysteine (R)-3-Ethylsulfanyl-2-(2-methylsulfanylmethyl-3-phenyl-propionylamino)-propionic acid

📜N-乙酰基-S-乙基-L-半胱氨酸置于pig Kidney Acylase I体系中,用 Phosphate Buffer 用作溶剂,化学反应 0.17H,反应生成S-乙基-L-半胱氨酸
参考文献:Acylase I-Catalyzed Deacetylation Of N-Acetyl-L-Cysteine And S-Alkyl-N-Acetyl-L-Cysteines
标题:Acylase I-Catalyzed Deacetylation Of N-Acetyl-L-Cysteine And S-Alkyl-N-Acetyl-L-Cysteines
摘要:The Aminoacylase That Catalyzes The Hydrolysis Of N-Acetyl-L-Cysteine (Nac) Was Identified As Acylase I After Purification By Column Chromatography And Electrophoretic Analysis. Rat Kidney Cytosol Was Fractionated By Ammonium Sulfate Precipitation,And The Proteins Were Separated By Ion-Exchange Column Chromatography,Gel-Filtration Column Chromatography,And Hydrophobic Interaction Column Chromatography. Acylase Activity With Nac And N-Acetyl-L-Methionine (Nam),A Known Substrate For Acylase I,As Substrates Coeluted During All Chromatographic Steps. Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis Showed That The Protein Was Purified To Near Homogeneity And Had A Subunit M-R Of 43 000,Which Is Identical With The M-R Of Acylase I From Porcine Kidney And Bovine Liver. N-Butylmalonic Acid Was A Slow-Binding Inhibitor Of Acylase I And Inhibited The Deacetylation Of Nac With A K-I Of 192 +/-27 Mu M These Results Show That Acylase I Catalyzes The Deacetylation Of Nag. The Acylase I-Catalyzed Deacetylation Of A Range Of S-Alkyl-N-Acetyl-L-Cysteines,Their Carbon And Oxygen Analogues,And The Selenium Analogue Of Nam Was Also Studied With Porcine Kidney Acylase I. The Specific Activity Of The Acylase I-Catalyzed Deacetylation Of These Substrates Was Related To Their Calculated Molar Volumes And Lag P Values. The S-Alkyl-N-Acetyl-L-Cysteines With Short (C-0-C-3) And Unbranched S-Alkyl Substituents Were Good Acylase I Substrates,Whereas The S-Alkyl-N-Acetyl-L-Cysteines With Long (>C-3) And Branched S-Alkyl Substituents Were Poor Acylase I Substrates. The Carbon And Oxygen Analogues Of S-Methyl-N-Acetyl-L-Cysteine And The Carbon Analogue Of S-Ethyl-N-Acetyl-L-Cysteine Were Poor Acylase I Substrates,Whereas The Selenium Analogue Of Nam Was A Good Acylase I Substrate.
Doi:10.1021/tx980018B

专利信息

专利号:US-7459443-B2
优先权日:1999-04-08
标 题 :Synthesis of biologically active compounds in cells
发明人：SERGEEV PAVEL
权利人:SERGEEV PAVEL
摘要:This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of determined sequence. The method is based on the hybridization of two or more oligomers bound with biologically inactive precursors of biologically active substances to specific RNA or DNA in vivo in the cells of living organisms. After hybridization of the oligomers to RNA or DNA the biologically inactive precursors bound to the 5′ and/or 3′ ends of the oligomers can interact with each other to make biologically active form of the substances. This changing of properties is due to chemical reactions which bind the biologically inactive precursors through a chemical bond into a biologically active form of the whole compound.

专利号:US-2005026143-A1
优先权日:1999-04-08
标 题:Synthesis of biologically active compounds in cells

专利号:US-2003104389-A1
优先权日:1999-04-08
标 题:Synthesis of biologically active compounds in cells

专利号:US-5514694-A
优先权日:1992-09-21
标题 :Peptidyl ketoamides
发明人：POWERS JAMES C; LI ZHAOZHAO; PATIL GIRISH S; CHU DER-LUN
权利人:GEORGIA TECH RES INST
摘要:A novel class of peptide alpha -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y-CO-AA2-AA1-CO-NH-X. Processes for the synthesis of peptidyl alpha -ketoamide derivatives.

专利号:US-8518885-B2
优先权日:2008-02-06
标题 :Heterocyclic peptide ketoamides
发明人：POWERS JAMES C; GLASS JONATHAN D; OVAT ASLI; LI ZHAOZHAO
权利人:POWERS JAMES C; GLASS JONATHAN D; OVAT ASLI; LI ZHAOZHAO; GEORGIA TECH RES INST; UNIV EMORY
摘要:A novel class of peptide α-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA 2 -AA 1 -CO—NH—(CH 2 ) n —R 3 . Processes for the synthesis of peptidyl α-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.

专利号:US-6831071-B2
优先权日:1999-04-08
标题:Synthesis of biologically active compounds in cells