CAS: 162359-55-9; 2-Amino-2-(4-Octylphenethyl)Propane-1,3-Diol

上下游产品

2-硝基去氨基芬戈莫德 2-(4-Octylphenyl)Ethyl-2-Nitro-1,3-Propanediol 374077-88-0
N-(1-羟基-2-(羟基甲基)-4-(4-辛基苯基)-2-丁基)乙酰胺 N-(1-Hydroxy-2-(Hydroxymethyl)-4-(4-Octylphenyl)Butan-2-yl)Acetamide 249289-10-9
乙酸-[2-(4-辛基苯基)]乙醇 2-(4-Octylphenyl)Ethanol 162358-05-6
1-(3-硝基丙基)-4-辛基苯 1-(3-Nitropropyl)-4-Octylbenzene 374077-87-9
4-(2-碘代乙基)辛基苯 1-(2-Iodoethyl)-4-Octylbenzene 162358-07-8
1-苯基辛烷 Octylbenzene 2189-60-8
Diethyl 2-Amino-2-(4-Octylphenethyl)Malonate 162358-62-5
N-[1,4-Dihydroxy-2-(Hydroxymethyl)-4-(4-Octylphenyl)Butan-2-Yl]Acetamide 4-Octylstyrene 46745-66-8

(4-octanoylphenyl)Methyl-Triphenylphosphanium;Bromide置于甲醇,Sodium Tetrahydroborate,水,Potassium Carbonate,三氟乙酸体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,5.0~75.0 °C,101.33 Kpa 条件下,反应生成2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
参考文献: Intermediate Compounds And Process For The Preparation Of Fingolimod[fr] Composés Intermédiaires Et Procédé De Préparation De Fingolimod
标题: Intermediate Compounds And Process For The Preparation Of Fingolimod[fr] Composés Intermédiaires Et Procédé De Préparation De Fingolimod

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:WO-2012150292-A1
优先权日:2011-05-03
标题:Stereoselective synthesis of cis-4-methylsphingosine and derivatives thereof
发明人：ARENZ CHRISTOPH; PROKSCH DENNY
权利人:UNIV BERLIN HUMBOLDT; ARENZ CHRISTOPH; PROKSCH DENNY
摘要:The invention provides for synthesis of a (S-R) dihydroxy-amino-methylalkylene characterized by the general formula I, or its R-S diastereomer, wherein R1 is CH2OH or CH2-CH2OH, and R2 is C2 to C20 alkyl, whereby a compound characterized by the general formula II, with R3, R4 and R5 being protecting groups for amino and hydroxyl functions, respectively, is used as a starting material. The invention further provides novel intermediates for syntheses of, and analogues to, cis-4-methylsphingosine.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-11649285-B2
优先权日:2016-08-03
标题 :Identification of VSIG3/VISTA as a novel immune checkpoint and use thereof for immunotherapy
发明人：KALABOKIS VASSILIOS; WANG JINGHUA; WU GUOPING; BAZAN JOSE FERNANDO; VALLEY CHRISTOPHER CARLIN
权利人:BIO TECHNE CORP
摘要:The ligand for VISTA is identified (VSIG3) as well as the use of this ligand and receptor interaction in the identification or synthesis of a VSIG3 agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG3 and/or VISTA and/or the VSIG3/VISTA interaction. These antagonists may be used to suppress VSIG3/VISTA's suppressive effects on T cell immunity, and more particularly used in the treatment of cancer, or infectious disease. These agonist compounds may be used to potentiate or enhance VSIG3/VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity, such as in the treatment of autoimmunity, allergy or inflammatory conditions. Screening assays for identifying these agonists and antagonist compounds are also provided.

专利号:US-2022251128-A1
优先权日:2019-05-17
标 题:Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages
发明人：MCPHERSON ANDREW K; RODRIGUEZ ANDREW A; CAPALDI DANIEL C
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwanted phosphate diester impurities in oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage.

专利号:US-10865163-B2
优先权日:2017-12-20
标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
发明人：YOUNG MICHAEL C; KAPOOR MOHIT
权利人:UNIV TOLEDO
摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.