CAS: 126-38-5; 1-Bromo-2,2-Dimethoxypropane

相似化合物

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上下游产品

CAS号598-31-2 溴丙酮 | CAS号149-73-5 原甲酸三甲酯 | CAS号67-56-1 甲醇 | CAS号926-66-9 2-乙氧基丙烯 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号85333-43-3 8-氯-2-甲基咪唑并[1,2-a]吡嗪 | CAS号598-31-2 溴丙酮 | CAS号62359-07-3 2-ethyl-N,N-dim...

溴丙酮,原甲酸三甲酯置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 2.0H,以87.2%的收率获得1-溴-2,2-二甲氧基丙烷
参考文献:一种新的合成1-溴-2,2-二甲氧基丙烷的方法
标题:一种新的合成1-溴-2,2-二甲氧基丙烷的方法
摘要:本发明属于生物医药中间体技术领域,提出了一种新的合成1‑溴‑2,2‑二甲氧基丙烷的方法,包括以下步骤:S1.溴化反应:将丙酮溶解在二氯甲烷中,预热至65°C,加入溴素,温度控制在65~75°C,反应11~13H,得到1‑溴丙酮;S2.上保护反应:将1‑溴丙酮溶解在甲醇中,加入原甲酸三甲酯和浓盐酸,反应2~3小时,得到1‑溴‑2,2‑二甲氧基丙烷.通过上述技术方案,解决了现有技术中合成1‑溴‑2,2‑二甲氧基丙烷的方法使用危险品,收率低,产物难纯化的问题.

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-5663449-A
优先权日:1989-05-19
标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines

专利号:CN-107739328-A
优先权日:2017-11-22
标 题 :The preparation method of the key intermediate 1 for the synthesis of baricitinib

专利号:US-5637710-A
优先权日:1989-05-19
标题:Intermediate compounds in the synthesis of heteroarylpiperidines and piperazines

专利号:CN-120136877-A
优先权日:2023-12-04
标 题 :Synthesis method of 6-chloro-2, 8-dimethylimidazo [1,2-B ] pyridazine