CAS: 944476-44-2; Sofosbuvir Impurity 8

英文名称Sofosbuvir Impurity 8
中文名称索磷布韦杂质8
IUPAC名称((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
其它别名Sofosbuvir Dibenzoyl Dione Impurity; [(2R,3R,4R,5R)-3-Benzoyloxy-5-(2,4-Dioxopyrimidin-1-Yl)-4-Hydroxy-4-Methyloxolan-2-Yl]Methyl Benzoate; Uridine, 2'-C-Methyl-, 3',5'-Dibenzoate
CAS编号944476-44-2
FDA UNII编号:VH86A7D9D6
分子式:C24H22N2O8分子量:466.45
产品CID: 1995146
产品分类有机原料→分子砌块→手性化合物→手性砌块

相似结构搜索
InChIKey: SYOIECTUIXEQLV-PDKZGUECSA-N
InChI=1S/C24H22N2O8/c1-24(31)19(34-21(29)16-10-6-3-7-11-16)17(14-32-20(28)15-8-4-2-5-9-15)33-22(24)26-13-12-18(27)25-23(26)30/h2-13,17,19,22,31H,14H2,1H3,(H,25,27,30)/t17
计算化学: 氢键受体数9.0氢键供体数2.0可旋转键数6.0

相似化合物

114262-49-6 31448-54-1 1496551-71-3

MSDS等安全信息

上下游产品

24H20N2O7C24H20N2O7 (2R,3R,3aS,9aR)-3-hydroxy-2-(hydroxymethyl)-3a-methyl-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one benzoyl chloride 1-(2'-C-methyl-β-D-arabinofuranosyl)uracil(2'R)-2'-deoxy-2'-fluoro-2-methyluridine-3',5'-dibenzoate

合成工艺路线路线简述

12211-52-8 + 994-30-9 + 25581-41-3 + 922-67-8 + 98-88-4 = 944476-44-2
反应条件:1.1S:Thf,-78°C2.1S:H2O,Rt2.2R:H+,Rt3.1R:1H-Imidazole,S:Dmf,Rt4.1R:Alh(Bu-I)2,S:Ch2Cl2,-78°C4.2R:Dowex 50W,S:H2O,S:Et2O,-78°C5.1R:Nh4Oh,S:H2O,80°C6.1R:Dbu,S:H2O,S:Etoh,Reflux7.1S:C5H5N,Rt8.1R:P-Mec6H4So3H,S:Mecn,Reflux
标题:Anomeric Stereospecific Synthesis Of 2'-C-Methyl β-Nucleosides; The Holy Reaction Of Cyanamide With 2-C-Methyl-D-Arabinose
作者:By Jenkinson,Sarah F. Et Al
参考文献:Tetrahedron Letters 日期:2007 卷标:48(25) 页码:4441-4444