CAS: 92823-03-5; Sodium (6R,7R)-7-(2-((Difluoromethyl)Thio)Acetamido)-3-(((1-(2-Hydroxyethyl)-1H-Tetrazol-5-yl)Thio)Methyl)-7-Methoxy-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

该化合物是一种主要用于抗菌特性的广谱胸腺素抗生素,主要用于抗菌性能,对各种抗菌性和抗菌性细菌有效,有助于治疗病原体造成的感染;该化合物的特点是能够抗水,通过某些乙型乳腺来增强抗抗菌菌菌株的功效;Flomoxe 钠通常通过注射进行,以较低的毒性特征而闻名;其药用植物基因技术包括良好的组织渗透和有利的半衰期,允许有效施药治疗;该物质经常在临床环境中用于治疗呼吸道感染,尿道感染和皮肤感染;与任何抗生素发展的潜力一样,需要认真考虑其使用,并且遵守适当规定以降低这一风险的准则十分重要.总的来说,Flomoxe 钠是抗微生物素在抗微生物疗法库中的宝贵选择.

英文名称Sodium (6R,7R)-7-(2-((Difluoromethyl)Thio)Acetamido)-3-(((1-(2-Hydroxyethyl)-1H-Tetrazol-5-yl)Thio)Methyl)-7-Methoxy-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
中文名称氟氧头孢钠
IUPAC名称sodium (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
其它别名Flomoxefum; (6R,7R)-7-[[2-[(Difluoromethyl)Thio]Acetyl]Amino]-3-[[[1-(2-Hydroxyethyl)-1H-Tetrazol-5-Yl]Thio]Methyl]-7-Methoxy-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monosodium Salt; Fmox Sodium Salt
CAS编号92823-03-5
FDA UNII编号:445HIB8XNF
分子式:C15H17F2N6NaO7S2
分子量:518.46
产品CID: 1966978
同类组份化合物CAS99665-00-6 (free acid)92823-03-5 (sodium)
产品分类原料药 → 抗生素类药物 → 头孢菌素类药

相似结构搜索
InChIKey: PPPZBOLFWGINKN-YLCXCWDSSA-M
VABYRTVNDYMGRE-LODGIZPENA-N…
计算化学: 氢键受体数14.0氢键供体数3.0可旋转键数11.0

MSDS等安全信息

上下游产品

flomoxef (6R,7R)-7-(amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]°Ct-2-ene-2-formic acid diphenylmethyl ester (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]°Ct-2-ene-2-formic acid diphenylmethyl ester (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylate

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主要参考文献

1: Lee CH, Chen IL, Li CC, Chien CC. Clinical benefit of ertapenem compared to flomoxef for the treatment of cefotaxime-resistant Enterobacteriaceae bacteremia. Infect Drug Resist. 2018 Feb 23;11:257-266. doi: 10.2147/IDR.S146923. eCollection 2018.
2: Yu X, Wang F, Li J, Shan W, Zhu B, Wang J. Separation and characterization of unknown impurities and isomers in flomoxef sodium by LC-IT-TOF MS and study of their negative-ion fragmentation regularities. J Pharm Biomed Anal. 2017 Jun 5;140:81-90. doi: 10.1016/j.jpba.2017.03.032. Epub 2017 Mar 19. doi: 10.1016/j.diagmicrobio.2015.12.001. Epub 2015 Dec 11. doi: 10.1016/j.ijantimicag.2015.07.020. Epub 2015 Sep 7. doi: 10.1128/AAC.00701-15. Epub 2015 Jun 22.
6: Cui L, Li Y, Lv Y, Xue F, Liu J. Antimicrobial resistance surveillance of flomoxef in China. J Infect Chemother. 2015 May;21(5):402-4. doi: 10.1016/j.jiac.2015.01.008. Epub 2015 Jan 30. doi: 10.1016/j.diagmicrobio.2015.01.001. Epub 2015 Jan 9. doi: 10.1016/j.ijantimicag.2014.11.012. Epub 2014 Dec 31. doi: 10.1002/bmc.2968. Epub 2013 Jun 18. doi: 10.1186/1471-2334-12-206.

合成参考文献

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摘要:Xu, C.; Shao, X.; Shen, Q., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 1.
参考文献:10.1007/s101560200011
摘要:Tanaka M, Nakayama H, Tunoe H, Egashira T, Kanayama A, Saika T, Kobayashi I, Naito S. A remarkable reduction in the susceptibility of Neisseria gonorrhoeae isolates to cephems and the selection of antibiotic regimens for the single-dose treatment of gonococcal infection in Japan. J Infect Chemother. 2002 Mar;8(1):81–6. doi: 10.1007/s101560200011.
参考文献:10.1007/s00534-011-0393-6
摘要:Okano K, Kakinoki K, Suto H, Oshima M, Kashiwagi H, Yamamoto N, Akamoto S, Fujiwara M, Takama T, Usuki H, Hagiike M, Suzuki Y. Persisting ratio of total amylase output in drain fluid can predict postoperative clinical pancreatic fistula. J Hepatobiliary Pancreat Sci. 2011 Nov;18(6):815–20. doi: 10.1007/s00534-011-0393-6.
参考文献:10.1007/bf02033070
摘要:Reinert RR, Kaufhold A, Kierdorf H. Penicillin-resistant pneumococcus in community-acquired bacteremic pneumonia in Germany. Infection. 1992 Jul;20(4):238–9. doi: 10.1007/bf02033070.