CAS: 921617-76-7; 4-(5-(P-Tolyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl)Benzenesulfonic Acid

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相似化合物

170569-87-6 170571-01-4 457639-26-8

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    上下游产品

    4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione 4-hydrazino-benzenesulfonic acid 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide para-methylacetophenone4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride

    合成工艺路线路线简述

    • 合成目标产物 Celecoxib Impurity 22 主要起始原料 4,4,4-Trifluoro-1-(P-Tolyl)-1,3-Butanedione And 4-Hydrazinobenzenesulfonic Acid
    • 2757813-63-9 = 921617-76-7
      反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol; 16 H,35 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
      标题:Primary Sulfonamide Functionalization Via Sulfonyl Pyrroles: Seeing The N-Ts Bond In A Different Light
      作者:Ozaki,Tomoya; Yorimitsu,Hideki; Perry,Gregory J. P.
      参考文献:Chemistry - A European Journal 日期:2021 卷标:27(62) 页码:15387-15391]

      169590-42-5 = 921617-76-7
      反应条件:1.1 Reagents: Benzaldehyde,Potassium Carbonate Catalysts: 5H-Pyrrolo[2,1-C]-1,2,4-Triazolium,6,7-Dihydro-2-(2,4,6-Trimethylphenyl)-,Chlo... Solvents: Ethanol; 18 H,78 °C; 78 °C -> Rt1.2 Reagents: Hydrogen Peroxide,Tungstic Acid (H2Wo4) Solvents: Water; 0 °C; 6 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,Rt
      标题:Nhc-Catalyzed Deamination Of Primary Sulfonamides: A Platform For Late-Stage Functionalization
      作者:Fier,Patrick S.; Maloney,Kevin M.
      参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(4) 页码:1441-1445]

      720-94-5 + 16938-38-8 = 921617-76-7
      反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Isopropanol; 55 - 65 °C; 1.5 H,55 - 65 °C
      标题:Preparation Method Of Celecoxib Genotoxic Impurity
      参考文献:China]

      720-94-5 + 98-71-5 = 921617-76-7
      反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; Rt -> Reflux; 20 H,Reflux
      标题:Synthesis Of Carbon-11 Labeled Celecoxib Derivatives As New Candidate Pet Radioligands For Imaging Of Inflammation
      作者:Gao,Mingzhang; Wang,Min; Miller,Kathy D.; Hutchins,Gary D.; Zheng,Qi-Huang
      参考文献:Applied Radiation And Isotopes 日期:2009 卷标:67(11) 页码:2019-2024]

      720-94-5 + 98-71-5 = 921617-76-7
      反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; Rt -> Reflux; 8 H,Reflux; Reflux -> Rt
      标题:New Celecoxib Derivatives As Anti-Inflammatory Agents
      作者:Szabo,Gyoergy; Fischer,Janos; Kis-Varga,Agnes; Gyires,Klara
      参考文献:Journal Of Medicinal Chemistry 日期:2008 卷标:51(1) 页码:142-147]

      720-94-5 + 98-71-5 = 921617-76-7
      反应条件:1.1 Solvents: Ethanol; > 1 H,Rt -> Reflux
      标题:Safe Pharmaceutical Composition Containing Celecoxib For Treating Rheumatoid Arthritis And Osteoarthritis
      参考文献:China]

      = 921617-76-7 [标题:Reaction Conditions
      标题:Preparation Of 1,2-Diarylpyrazoles As Analgesics And Antiinflammatories.
      参考文献:World Intellectual Property Organization
    📜塞来西布置于对甲苯磺酸一水合物,Potassium Hydroxide体系中,用 乙醇,甲苯 作为反应溶剂,化学反应 17.0H,反应生成 塞来昔布杂质p
    参考文献:通过磺酰基吡咯进行初级磺酰胺官能化:从不同的角度观察 N-Ts 键
    标题:通过磺酰基吡咯进行初级磺酰胺官能化:从不同的角度观察 N-Ts 键
    摘要:磺胺类药物在药物分子中很普遍,然而,通过 S-N 键裂解功能化磺胺类药物的方法很少.基于对 N-Ts 脱保护的重新评估,我们开发了磺酰吡咯作为磺酰胺功能化的关键.磺酰基吡咯参与可以通过化学,电化学或光化学途径进行的各种转化.
    DOI:10.1002/chem.202102748

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