CAS: 920-46-7; Methacryloyl Chloride

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CAS号79-10-7 丙烯酸 | CAS号79-41-4 甲基丙烯酸 | CAS号78-85-3 2-甲基丙烯醛 | CAS号7623-10-1 3-chloro-2-meth... | CAS号98-09-9 苯磺酰氯 | CAS号760-93-0 甲基丙烯酸酐 | CAS号368-44-5 phenyldichlorof... | CAS号98-88-4 苯甲酰氯 | CAS号108501-85-5 N-(2-iodophenyl... | CAS号108871-76-7 methyl 4-(2-met... | CAS号106089-24-1 (R)-1-Methacryl... | CAS号4655-34-9 甲基丙烯酸异丙酯 | CAS号3934-23-4 1H,1H-甲基丙烯酸全氟辛酯 | CAS号3253-41-6 2,2-bis[[(2-met... | CAS号585-07-9 甲基丙烯酸叔丁酯 | CAS号355-93-1 甲基丙烯酸1H,1H,5H-八氟戊酯 | CAS号352-87-4 甲基丙烯酸三氟乙酯 | CAS号3253-39-2 4,4'-异亚丙基二苯酚二甲基烯丙酸酯

丙烯酸置于n,N-二甲基甲酰胺 草酰氯体系中,化学反应 0.17H,以99%的收率获得产物甲基丙烯酰氯
参考文献: Process For Forming Alpha,Beta-Unsaturated Carbonyl Halides[fr] Procédé Pour Former Des Halogénures De Carbonyle Alpha,Bêta-Insaturés
标题: Process For Forming Alpha,Beta-Unsaturated Carbonyl Halides[fr] Procédé Pour Former Des Halogénures De Carbonyle Alpha,Bêta-Insaturés
摘要:描述了在微反应器中形成α,β-不饱和羰基卤化物的过程.反应物包括α,β-不饱和羧酸,卤化剂和催化剂.第一入口流,第二入口流和可选的第三入口流流入流经微反应器的反应室,形成包含α,β-不饱和羰基卤化物的反应产物.

专利信息

专利号:US-7199257-B1
优先权日:1999-06-10
标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
发明人：SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS
权利人:RICHTER GEDEON VEGYESZET
摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-10011567-B1
优先权日:2017-03-09
标题 :Method for the synthesis of acrylate derivatives
发明人：WANG MINGWEN; ZHANG YUE
权利人:INNOSCI LLC
摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.

专利号:US-7759520-B2
优先权日:1996-11-27
标 题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; YIN DONGHUA; HE YALI
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-12338202-B2
优先权日:2021-09-10
标 题 :One pot synthesis of urea (meth)acrylates
发明人：BESTGEN SEBASTIAN; BEYER SILVIA
权利人:EVONIK OPERATIONS GMBH
摘要:A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.

专利号:US-6995284-B2
优先权日:2000-08-24
标题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.