CAS: 80983-36-4; 5-(Propylthio)-1H-Benzo[d]Imidazol-2-Amine

该化合物是一种化学化合物,其独特的结构特征包括以丙基磺酰胺组和氨基组取代的苯并米二甲醇核心,该化合物通常具有与异环化合物相关的特性,包括由于苯并二甲酰胺在各种药理应用中发挥作用而闻名的潜在生物活动.丙基磺酰氟组可能影响该化合物的溶性和再活动,有可能增强它与生物目标的相互作用.就物理特性而言,这种性质的化合物通常具有中度至高度的熔点,并可能在有机溶剂中溶解.氨基化合物的存在还可能具有基本性,影响该化合物在不同pH环境中的行为.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号54965-21-8 阿苯达唑

合成工艺路线路线简述

  • 66608-52-4 + 21729-98-6 = 80983-36-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water2.1 Reagents: Sulfuric Acid Solvents: Water; 25 °C -> 100 °C; 16 H,100 °C; 100 °C -> 25 °C2.2 Reagents: Water; Cooled2.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    54393-89-4 = 80983-36-4
    反应条件:1.1 Reagents: Sodium Hydrosulfide Solvents: Water; Heated2.1 Reagents: Sodium Hydroxide Solvents: Water3.1 Reagents: Sulfuric Acid Solvents: Water; 25 °C -> 100 °C; 16 H,100 °C; 100 °C -> 25 °C3.2 Reagents: Water; Cooled3.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    54965-21-8 = 80983-36-4
    反应条件:1.1 Reagents: Diethylenetriamine Solvents: Diethylenetriamine; 12 H,130 °C
    标题:Diethylenetriamine-Mediated Direct Cleavage Of Unactivated Carbamates And Ureas
    作者:Noshita,Megumi; Et Al
    参考文献:Organic Letters 日期:2016 卷标:18(23) 页码:6062-6065]

    75-12-7 + 2254177-01-8 = 80983-36-4
    反应条件:1.1 Reagents: Cesium Carbonate,Ammonia Catalysts: 8-Hydroxyquinoline,Nickel Dichloride Solvents: Water; Rt -> 100 °C; 13 Min,100 °C; 100 °C -> Rt1.2 Reagents: Water
    标题:Microwave-Assisted Nickel-Catalyzed Synthesis Of Benzimidazoles: Ammonia As A Cheap And Nontoxic Nitrogen Source
    作者:Ke,Fang; Et Al
    参考文献:Synlett 日期:2018 卷标:29(20) 页码:2722-2726]

    66608-52-4 = 80983-36-4
    反应条件:1.1 Reagents: Dimethyl Sulfate Solvents: Water; 25 - 30 °C; 24 H,85 - 90 °C; 90 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 7.0 - 7.5,Rt1.3 Solvents: Ethyl Acetate; 10 Min,Rt1.4 Reagents: Acetic Acid; Rt; 8 H,55 - 60 °C; 60 °C -> Rt; 1 H,Rt
    标题:Synthesis And Antimicrobial Activity Of Novel 1H-Benzo[d]Imidazole-Aryl Sulfonamide/amide Derivatives
    作者:Jadhav,Rahul I.; Et Al
    参考文献:Indian Journal Of Chemistry (2022-) 日期:2022 卷标:61(2) 页码:184-191]

    2986-19-8 + 66608-52-4 = 80983-36-4
    反应条件:1.1 Reagents: Acetic Acid Solvents: Ethyl Acetate; 8 H,55 - 60 °C; 60 °C -> Rt; 1 H,Rt
    标题:Synthesis And Antimicrobial Activity Of Novel 1H-Benzo[d]Imidazole-Aryl Sulfonamide/amide Derivatives
    作者:Jadhav,Rahul I.; Et Al
    参考文献:Indian Journal Of Chemistry (2022-) 日期:2022 卷标:61(2) 页码:184-191]

    1762-95-4 = 80983-36-4
    反应条件:1.1 Reagents: Chlorine Solvents: Methanol; 6 H,23 - 25 °C; 2 H,23 - 25 °C2.1 Reagents: Sodium Hydroxide Solvents: Water; Basified3.1 Reagents: Sodium Hydrosulfide Solvents: Water; Heated4.1 Reagents: Sodium Hydroxide Solvents: Water5.1 Reagents: Sulfuric Acid Solvents: Water; 25 °C -> 100 °C; 16 H,100 °C; 100 °C -> 25 °C5.2 Reagents: Water; Cooled5.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    1943734-28-8 = 80983-36-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Basified2.1 Reagents: Sodium Hydrosulfide Solvents: Water; Heated3.1 Reagents: Sodium Hydroxide Solvents: Water4.1 Reagents: Sulfuric Acid Solvents: Water; 25 °C -> 100 °C; 16 H,100 °C; 100 °C -> 25 °C4.2 Reagents: Water; Cooled4.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    54965-21-8 = 80983-36-4 + 105530-57-2
    反应条件:1.1 Solvents: Ethanol; 8.5 H
    标题:Photo- And Thermal-Stability Studies On Benzimidazole Anthelmintics By Hplc And Gc-Ms
    作者:Ragno,Gaetano; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:2006 卷标:54(6) 页码:802-806
📜阿苯达唑置于氢溴酸体系中,化学反应 19.0H,以69%的收率获得产物5-苯硫基-1H-苯并咪唑-2-胺
参考文献:Synthesis And Anthelmintic Evaluation Of Novel Valerolactam-Benzimidazole Hybrids
标题:Synthesis And Anthelmintic Evaluation Of Novel Valerolactam-Benzimidazole Hybrids
摘要:基于具有驱虫活性的两个结构域的结合,构建了一些新颖的5(6)-取代-(1H-苯并咪唑-2-氨基)戊内酰胺衍生物.与市售的苯并咪唑类驱虫药相比,通过采用基于巴西钩口线虫生理学的体外生物测定试验,测试的杂化化合物7-9表现出更高的活性.此外,与戊内酰胺结构域相比,杂化化合物改善的物理化学性质使得它们能穿透寄生虫屏障,同时增加了寄生虫体内的生物利用度.
DOI:10.2174/15701808113109990028

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Microwave-Assisted Nickel-Catalyzed Synthesis Of Benzimidazoles: Ammonia As A Cheap And Nontoxic Nitrogen Source
作者:Fang Ke,Peng Zhang,Yiwen Xu,Xiaoyan Lin,Jin Lin,Chen Lin,Jianhua Xu |发布日期:2018.12
摘要:Efficient And Convenient Ni-Catalyzed C-N Bond Formation For The Synthesis Of Various Benzimidazoles From Various 2-Haloanilines, Aldehydes, And Ammonia In A Concise Manner Is Reported. This Protocol Uses Commercially Available, Nonhazardous, Clean Ammonia As A Reaction Partner Instead Of Other Nitrogen Sources. Benzimidazoles, As The Sole Products, Were Obtained In High To Excellent Yields (Up To 95%)

合成参考文献


参考文献:10.1055/s-0037-1610843
摘要:Ke F, Zhang P, Xu Y, Lin X, Lin J, Lin C, Xu J. Microwave-Assisted Nickel-Catalyzed Synthesis of Benzimidazoles: Ammonia as a Cheap and Nontoxic Nitrogen Source. Synlett. 2018 Nov 23;29(20):2722–6. doi: 10.1055/s-0037-1610843.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知