CAS: 70132-50-2; 1-(2-Nitro-1H-Imidazol-1-yl)-3-(Piperidin-1-yl)Propan-2-Ol
该化合物是一种硝基胺氮基低氧氧化物标记,广泛用于生物医学研究,以识别和研究组织中的缺氧区域,在低氧条件下有选择地与缺氧细胞结合的能力使它成为调查肿瘤缺氧,缺氧,缺血,缺氧和其他缺氧环境的宝贵工具. Pimonidazole 以细胞大型分子形成稳定的吸附管道,通过免疫生物学化学或流动细胞测量进行精确的检测.它的高度特性和敏感性使研究人员能够量化临床前模型中与缺氧有关的过程,协助研究癌症生物学,放射疗法抗力和治疗目标.该化合物的可靠性和特性良好的再活动有助于其在实验和诊断应用中广泛使用.
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2922110001-单乙醇胺
2922192100-二甲氨基乙醇
2922192210-2-二乙氨基乙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2019018655-A1
优先权日:2017-07-19
标题:SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
发明人：DRIESSCHAERT BENOIT; KHRAMTSOV VALERY
权利人:UNIV WEST VIRGINIA
摘要:The present invention provides compositions and methods relating to paramagnetic probes for EPR spectroscopy. The present invention provides compositions and methods for biocompatible paramagnetic probes that can be targeted to a target in vitro or in vivo, and can provide a monofunctional or multifunctional measurement of a number of physiological parameters of cells or tissue. in vitro or in vivo, individually or in combination. The invention further relates to methods of using the compositions created by the methods of the invention.
专利号:US-7994222-B2
优先权日:2006-09-05
标 题:Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
发明人：OSSOVSKAYA VALERIA S; SHERMAN BARRY M
权利人:BIPAR SCIENCES INC
摘要:The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.
专利号:AU-2007292306-A1
优先权日:2006-09-05
标 题 :Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
专利号:US-2008103208-A1
优先权日:2006-09-05
标题:Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
专利号:US-2012004260-A1
优先权日:2006-09-05
标 题 :Inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds and methods of treatment thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Masunaga S, Sakurai Y, Tanaka H, Hirayama R, Matsumoto Y, Uzawa A, Suzuki M, Kondo N, Narabayashi M, Maruhashi A, Ono K. Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction. Br J Radiol. 2013 Jan;86(1021):20120302. doi: 10.1259/bjr.20120302. doi: 10.1186/1748-717X-7-89.
5: Rademakers SE, Lok J, van der Kogel AJ, Bussink J, Kaanders JH. Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer. 2011 May 12;11:167. doi: 10.1186/1471-2407-11-167.
6: Donaldson SB, Betts G, Bonington SC, Homer JJ, Slevin NJ, Kershaw LE, Valentine H, West CM, Buckley DL. Perfusion estimated with rapid dynamic contrast-enhanced magnetic resonance imaging correlates inversely with vascular endothelial growth factor expression and pimonidazole staining in head-and-neck cancer: a pilot study. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1176-83. doi: 10.1016/j.ijrobp.2010.09.039. Epub 2011 May 4. doi: 10.3899/jrheum.100174. doi: 10.1016/j.ejca.2009.07.012. Epub 2009 Aug 19. doi: 10.1007/978-1-59745-352-3_12. doi: 10.1667/RR1400.1. doi: 10.1667/RR1305.1. doi: 10.1007/s00259-008-0772-7. Epub 2008 Apr 18. Erratum in: Eur J Nucl Med Mol Imaging. 2009 Feb;36(2):331. Epub 2007 Oct 1. Epub 2007 Aug 7. Epub 2006 Sep 7. Epub 2006 Aug 17.
合成参考文献
参考文献:10.1016/j.ijrobp.2009.09.045
摘要:Simonsen TG, Gaustad J, Rofstad EK. Development of Hypoxia in a Preclinical Model of Tumor Micrometastases. International Journal of Radiation Oncology*Biology*Physics. 2010 Mar;76(3):879–88. doi: 10.1016/j.ijrobp.2009.09.045.
参考文献:10.1186/1471-2407-5-152
摘要:Thorwarth D, Eschmann SM, Scheiderbauer J, Paulsen F, Alber M. Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer. BMC Cancer. 2005 Dec 01;5():152.
参考文献:10.1016/j.radonc.2011.06.022
摘要:Nijkamp MM, Hoogsteen IJ, Span PN, Takes RP, Lok J, Rijken PF, van der Kogel AJ, Bussink J, Kaanders JH. Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma. Radiother Oncol. 2011 Oct;101(1):165–70. doi: 10.1016/j.radonc.2011.06.022.
参考文献:10.4061/2011/764830
摘要:Hennings LJ, Flores R, Roberson PK, Brown A, Lowery J, Borrelli M, Culp WC. Persistent Penumbra in a Rabbit Stroke Model: Incidence and Histologic Characteristics. Stroke Research and Treatment. 2011;2011():1–6. doi: 10.4061/2011/764830.
📝 需求与反馈
尽可能描述清楚需求与问题信息
