CAS: 6543-77-7; Doxycyline

该化合物是抗生素四环乙烷的一种半合成衍生物,专门用来加强其抗菌特性,其特点是对各种克型阳性细菌和克型阴性细菌的广谱活动,使其有效治疗各种感染;该化合物具有复杂的四环结构,对其行动机制至关重要,主要包括抑制细菌蛋白合成,将其与30-S核子核子元素结合. 4-环氧环球物质在酸性环境中具有稳定性,可以提高其生物利用率.此外,该物质表现出相对较低的毒性特征,适合治疗用途.然而,与其他四环球病一样,该物质可能会产生副作用,如胃肠扰动和光敏度等,其使用还受到抗生素抗药性开发潜力的限制.

结构式图片

物理性质

MSDS等安全信息

    上下游产品

    CAS号564-25-0 强力霉素

    合成工艺路线路线简述

      📜强力霉素置于溶剂黄146体系中,化学反应 24.0H,以650 Mg的收率获得产物4-环氧氯丙烷强力霉素
      参考文献:Kertscher; Habermann; Pohle,Scientia Pharmaceutica,1998,Vol. 66,# 4,P. 287-296
      标题:Kertscher; Habermann; Pohle,Scientia Pharmaceutica,1998,Vol. 66,# 4,P. 287-296

      海关参考信息

      专利信息


      专利号:US-2021015837-A1
      优先权日:2020-04-08
      标题 :Method of Manufacturing an antiviral super treatment
      发明人：STAFFORD VIVI R
      权利人:STAFFORD VIVI R
      摘要:Method of Manufacturing an antiviral super pill or syrup for the treatment of viral infection such as SARS-CoV-2 (Covid 19). A cyclin antibiotic as well as a macrolide antibiotic are combined within the same compounded pill or capsule for the treatment of viruses. Doxycycline, a cyclin, binds to the 30S ribosomal subunit, and presumably to the 50S ribosomal subunit, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex, Azithromycin, a macrolide, reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. As a result, this combination can provide immunity from certain viruses, such as Coronavirus 2019 (Covid 19) when given at the same time of a nasopharyngeal exposure to virus particles within numbers greater or less than 1000 virions, as a treatment regimen for a cure or as a prophylaxis for those exposed or were presumably exposed.

      专利号:WO-2004046348-A1
      优先权日:2002-11-17
      标题:Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
      发明人：OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
      权利人:UNIV RAMOT; OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
      摘要:A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.

      专利号:US-2013236964-A1
      优先权日:2002-11-17
      标 题:Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
      发明人：MELAMED ELDAD; OFFEN DANIEL; LEVY YOSEF; GREEN PNINA
      权利人:UNIV RAMOT
      摘要:A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.

      其他信息查阅

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      实用工具

      ⚠️全国化工行业净网倡议书
      📋制造商识别码
      📖 海关编码查询
      📝MSDS生成器

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      合成参考文献

      参考DOI号:10.1021/ja01498a037
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知