📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于甲醇,Palladium On Activated Charcoal,溶剂黄146体系中,化学反应生成 甘氨酰甘氨酰-L-苯丙氨酸 参考文献:The Use Of Hydrogen Bromide In Acetic Acid For The Removal Of Carbobenzoxy Groups And Benzyl Esters Of Peptide Derivatives1 标题:The Use Of Hydrogen Bromide In Acetic Acid For The Removal Of Carbobenzoxy Groups And Benzyl Esters Of Peptide Derivatives1 摘要: DOI:10.1021/jo01366A011
专利号:US-2004053274-A1 优先权日:2002-09-04 标 题 :Gene cluster of vicenistatin biosynthesis, a vicenisamine glycosyltransferase polypeptide, and a gene encoding the polypeptide 发明人:KAKINUMA KATSUMI 权利人:TOKYO INST TECH 摘要:To achieve enzymatic production of vicenistatin, a valuable compound, this invention provides enzymes involved in biosynthesis of vicenistatin and genes encoding the enzymes. This invention provides base sequence of the vin cluster which encodes enzyme complex responsible for biosynthesis of vicenistatin. This invention further provides a glycosyltransferase (VinC enzyme), which catalyzes production of vicenistatin using dTDP-vicenisamine as a substrate. Moreover, this invention provides a gene (vinC gene) encoding the enzyme. The VinC enzyme is useful for enzymatic synthesis of valuable compound vicenistatin. Furthermore, it is suggested that use of the VinC enzyme will enable development of novel polyketide glycosides.
专利号:US-6004787-A 优先权日:1991-01-17 标题:Method of directing biosynthesis of specific polyketides 发明人:KATZ LEONARD; DONADIO STEFANO; MCALPINE JAMES B 权利人:ABBOTT LAB 摘要:A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific polyketide analogs is accomplished by genetic manipulation of a polyketide-producing microorganism by isolating a polyketide biosynthetic gene-containing DNA sequence, identifying enzymatic activities associated within the DNA sequence, introducing one or more specified changes into the DNA sequence which codes for one of the enzymatic activities which results in an altered DNA sequence, introducing the altered DNA sequence into the polyketide-producing microorganism to replace the original sequence, growing a culture of the altered microorganism under conditions suitable for the formation of the specific polyketide analog, and isolating the specific polyketide analog from the culture. The method is most useful when the segment of the chromosome modified is involved in an enzymatic activity associated with polyketide biosynthesis, particularly for manipulating polyketide synthase genes from Saccarharopolyspora or Streptomyces.
专利号:US-6600029-B1 优先权日:1995-12-19 标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases 发明人:SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN 权利人:UNIV MINNESOTA 摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.
专利号:US-6051383-A 优先权日:1995-06-26 标题:Sequences for production of 2,4-diacetylphloroglucinol and methods 发明人:THOMASHOW LINDA S; BANGERA MAHALAXMI; WELLER DAVID M; COOK R JAMES 权利人:US AGRICULTURE; UNIV WASHINGTON 摘要:DNA sequences which function specifically in the synthesis of 2,4-diacetylphloroglucinol (Phl) are described. The sequences include phl genes which encode phl gene proteins and coding and regulatory sequences for production of Phl as well as sequences containing phl genes, which sequences have the capability of conferring or enhancing Phl biosynthetic capability in bacterial strains. The transformed strains are useful as biocontrol agents against fungal pathogens.
专利号:US-6573076-B1 优先权日:1997-03-04 标 题:Gene, group of genes, and novel β-glucosidase 发明人:TONOUCHI NAOTO; TSUCHIDA TAKAYASU; YOSHINAGA FUMIHIRO; TAHARA NAOKI; YANO HISATO; HAYASHI TAKAHISA 权利人:AJINOMOTO KK 摘要:An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms.The present invention relates to a gene group encoding cellulase, cellulose synthase complex, beta-glucosidase and the like, and to novel beta-glucosidase.
专利号:US-6720485-B1 优先权日:1998-07-20 标 题:Controlling starch synthesis 发明人:SCHAFFER ARTHUR; LEVIN ILAN; PETREIKOV MARINA; BAR MOSHE 权利人:ISRAEL STATE 摘要:A method for controlling starch synthesis in tomatoes including providing a population of plants derived from interspecific crosses of Lycopersicon spp. with Lycopersicon esculentum genotypes, and selecting individuals of the population that each contain an allele of a gene that increases starch synthesis, the gene originating from the Lycopersicon spp.
参考文献:10.1007/bf00422908 摘要:Sikora L, Marzluf GA. Regulation of L-amino acid oxidase and of D-amino acid oxidase in Neurospora crassa. Molecular Genetics and Genomics. 1982 Jun;186(1):33–9. doi: 10.1007/bf00422908. 参考文献:10.1021/jm990226g 摘要:Ganellin CR, Bishop PB, Bambal RB, Chan SM, Law JK, Marabout B, Luthra PM, Moore AN, Peschard O, Bourgeat P, Rose C, Vargas F, Schwartz JC. Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J Med Chem. 2000 Feb 24;43(4):664–74. doi: 10.1021/jm990226g. 参考文献:10.1038/nchembio.132 摘要:Van Zeebroeck G, Bonini BM, Versele M, Thevelein JM. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol. 2009 Jan;5(1):45–52. doi: 10.1038/nchembio.132.