CAS: 552-41-0; 1-(2-Hydroxy-4-Methoxyphenyl)Ethanone

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CAS号89-84-9 2',4'-二羟基苯乙酮 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号5451-83-2 3-甲氧基苯基乙酸 | CAS号128961-25-1 1-(4-methoxy-2-... | CAS号829-20-9 2,4-二甲氧基苯乙酮 | CAS号150-19-6 3-甲氧基苯酚 | CAS号75-36-5 乙酰氯 | CAS号64-19-7 冰醋酸 | CAS号10493-06-8 2-Propen-1-one,... | CAS号490-78-8 2',5'-二羟基苯乙酮 | CAS号491-37-2 2,3-二氢苯并吡喃-4-酮 | CAS号42327-52-6 7-甲氧基-4H-1-苯并吡喃-4-酮 | CAS号22609-52-5 2-(4-chlorophen... | CAS号22089-12-9 1-(2,5-二羟基-4-甲氧... | CAS号708-53-2 2',3'-二羟基-4'-甲氧基苯乙酮 | CAS号20321-73-7 7-甲氧基-2,2-二甲基苯并... | CAS号20784-60-5 4'-O-甲基补骨脂查尔酮 | CAS号89-84-9 2',4'-二羟基苯乙酮

2,4-二羟基苯乙酮置于potassium Carbonate,碘甲烷体系中,用 丙酮 作为反应溶剂,化学反应生成 丹皮酚
参考文献:新型异黄酮/苯并-δ-Sultam杂化物的合成作为潜在的抗炎药
标题:新型异黄酮/苯并-δ-Sultam杂化物的合成作为潜在的抗炎药
摘要:合成了少量的新型异黄酮/苯并-δ-Sultam杂种,并将其评估为lps激活的bv2小胶质细胞中潜在的抗炎和神经保护药物.通过将2-卤代苯磺酰胺衍生物与末端炔烃偶联,然后进行6-Endo-Dig环化反应,可在两步反应中构建苯并-δ-Sultam核.测试了合成的化合物(包括前体和杂化物)在lps刺激的bv2小胶质细胞中抑制no和tnf-α产生的能力,结果令人鼓舞.在孔中最终浓度为20 µm时,最有效的杂种可将no反应生成量降低至41%,将tnf-α降低至34%.
DOI:10.1016/j.Bmcl.2020.127761

专利信息

专利号:US-11815463-B1
优先权日:2019-06-28
标 题:Reagent synthesis and testing assays to detect and quantify manganese (II)
发明人：HOLMES ANNA MERRITT; WADDELL EMANUEL AUSTIN
权利人:HOLMES ANNA MERRITT; WADDELL EMANUEL AUSTIN; BOARD OF TRUSTEES OF THE UNIV OF ALABAMA FOR AND ON BEHALF OF THE UNIV OF ALABAMA IN HUNTSVILLE
摘要:The present disclosure relates to methods of detecting manganese in a solution using resacetophenone oxime by spectrophotometric analysis wherein the resacetophenone oxime produces colorimetric responses to indicate the presence of manganese. The resacetophenone oxime is not only stable in solution, but it also may be inserted into a hydrocolloid gel to facilitate a “spot testâ€? for the detection of manganese, resulting in a long shelf life. These manganese testing methods disclosed herein may be used at the pre-disinfection process at water treatment facilities. The disclosed methods of manganese testing may be combined with an ammoniacal buffer reagent that may be used by water processing facilities, prior to final disinfection, to augment existing manganese (II) efforts of removal. A secondary flocculation with this buffer will scavenge additional manganese (II), that can then be removed by sedimentation or filtration.

专利号:US-5877296-A
优先权日:1994-06-03
标题:Process for preparing conjugates of methyltrithio antitumor agents
发明人：HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN
权利人:AMERICAN CYANAMID CO
摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

专利号:GB-2358016-A8
优先权日:2000-01-10
标 题 :The synthesis of (2-chloro or 2-bromo)-5,6,8-trihyThe synthesis of (2-chloro or 2-bromo)-5,6,8-trihydroxynaphtho-1,4,-quinone and their use in the predroxynaphtho-1,4,-quinone and their use in the preperation of kermesic acid peration of kermesic acid

专利号:US-9321804-B2
优先权日:2011-03-09
标题 :Synthesis and use of anti-tumor drug LQC-Y
发明人：LEI HAIMIN
权利人:UNIV BEIJING CHINESE MEDICINE; 3D MEDICINES LTD
摘要:Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg/kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.

专利号:US-3953604-A
优先权日:1972-01-14
标 题:1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
发明人：WARREN BRIAN THOMAS; SPICER JOHN WILLIAM
权利人:MILES LAB
摘要:Definitions: in the following Formulae I, II and IV, R 1 represents hydrogen, alkyl of 1 to 4 carbon atoms, or a nontoxic cation, while each of R 2 , R 3 , R 4 , R 5 , and R 6 symbolizes hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, carboxy, carbalkoxy of 1 to 4 carbon atoms, trihalomethyl, halogen, nitro or cyano. n Certain 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I), ##SPC1## n can be synthesized from intermediate bis-(substituted-phenoxy)propanes (Formula II), ##SPC2## n by condensation with diethyl oxalate in the presence of sodium ethoxide followed by cyclization with a mixture of glacial acetic acid and concentrated sulfuric or a mixture of concentrated hydrochloric acid and a lower alcohol containing up to 4 carbon atoms. n The bis-(substituted-phenoxy)propane intermediates (Formula II) are prepared by reacting a dihydroxyacetophenone (Formula III), ##SPC3## n with a (substituted-phenyl)glycidyl ether (Formula IV), ##SPC4## n in an organic solvent in the presence of a catalyst. n The 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I) are useful in the treatment of allergic conditions in mammals. The bis-(substituted-phenoxy)propanes (Formula II) are useful as intermediates in the synthesis of the latter compounds. Methods of preparing compounds having Formulae I and II are described. Methods of treating allergic conditions in mammals utilizing compounds of Formula I are also disclosed.

专利号:US-5739116-A
优先权日:1994-06-03
标题:Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents